PMID- 27026183
OWN - NLM
STAT- MEDLINE
DCOM- 20170707
LR  - 20181113
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 54
IP  - 4
DP  - 2017 May
TI  - Albumin and Protein Oxidation are Predictors that Differentiate 
      Relapsing-Remitting from Progressive Clinical Forms of Multiple Sclerosis.
PG  - 2961-2968
LID - 10.1007/s12035-016-9860-z [doi]
AB  - The aim of the present study was to evaluate inflammatory, oxidative, and 
      nitrosative stress (IO&NS) blood markers as possible predictors of multiple 
      sclerosis (MS) and its clinical forms. This study included 258 MS patients (175 
      with relapsing-remitting MS (RRMS) and 83 with progressive MS clinical forms) and 
      249 healthy individuals. Peripheral blood samples were obtained to determine 
      serum levels of albumin, ferritin, C-reactive protein (CRP), total protein, lipid 
      hydroperoxide by tert-butyl hydroperoxide-initiated chemiluminescence (CL-LOOH), 
      carbonyl protein content, advanced oxidation protein products (AOPP), nitric 
      oxide metabolites (NOx), and total radical-trapping antioxidant parameter (TRAP). 
      MS patients showed higher ferritin (p < 0.001) and CL-LOOH (p < 0.001) and lower 
      albumin (p = 0.001), TRAP (p < 0.001), AOPP (p = 0.013), and NOx values 
      (p < 0.001) than controls. Difference was not observed in CRP, total protein, and 
      carbonyl proteins between patients and controls. In the logistic regression 
      age-adjusted, ferritin and CL-LOOH showed positive association with MS and were 
      predictors of MS development (OR: 1.006, 95 % CI: 1.003-1.009, p < 0.001 and OR: 
      1.029, 95 % CI: 1.007-1.052, p = 0.009, respectively). Albumin, TRAP, AOPP, and 
      NOx were negatively associated with MS (p = 0.019, p = 0.003, p = 0.001, and 
      p = 0.003, respectively). Moreover, other logistic regression age-adjusted showed 
      that MS patients with progressive clinical forms had lower albumin and higher 
      AOPP than those with RRMS (p = 0.037). In conclusion, ferritin, albumin, and 
      biomarkers of IO&NS, such as CL-LOOH, AOPP, TRAP, and NOx were predictors of MS 
      diagnosis, whereas albumin and AOPP were predictors that differentiated RRMS from 
      the progressive clinical forms of MS.
FAU - Oliveira, Sayonara R
AU  - Oliveira SR
AD  - Postgraduate Program, Health Sciences Center, University of Londrina, Av. Robert 
      Koch, 60, 86038-440, Londrina, Parana, Brazil.
FAU - Kallaur, Ana Paula
AU  - Kallaur AP
AD  - Postgraduate Program, Health Sciences Center, University of Londrina, Av. Robert 
      Koch, 60, 86038-440, Londrina, Parana, Brazil.
FAU - Reiche, Edna M V
AU  - Reiche EMV
AD  - Department of Pathology, Clinical Analysis, and Toxicology, Health Sciences 
      Center, University Hospital, State University of Londrina, Av. Robert Koch 60, 
      Vila Operaria, CEP 86038-350, Londrina, Parana, Brazil.
FAU - Kaimen-Maciel, Damacio R
AU  - Kaimen-Maciel DR
AD  - Department of Clinical Medicine, Health Sciences Center, University of Londrina, 
      Av. Robert Koch, 60, 86038-440, Londrina, Parana, Brazil.
FAU - Panis, Carolina
AU  - Panis C
AD  - Laboratory of Inflammatory Mediators, University of West Parana, UNIOESTE, Campus 
      Francisco Beltrao, Parana, Brazil.
FAU - Lozovoy, Marcell Alysson B
AU  - Lozovoy MAB
AD  - Department of Pathology, Clinical Analysis, and Toxicology, Health Sciences 
      Center, University Hospital, State University of Londrina, Av. Robert Koch 60, 
      Vila Operaria, CEP 86038-350, Londrina, Parana, Brazil.
FAU - Morimoto, Helena K
AU  - Morimoto HK
AD  - Department of Pathology, Clinical Analysis, and Toxicology, Health Sciences 
      Center, University Hospital, State University of Londrina, Av. Robert Koch 60, 
      Vila Operaria, CEP 86038-350, Londrina, Parana, Brazil.
FAU - Maes, Michael
AU  - Maes M
AD  - IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, 
      VIC, Australia.
FAU - Dichi, Isaias
AU  - Dichi I
AD  - Department of Internal Medicine, University of Londrina, Londrina, Parana, 
      Brazil.
FAU - Simao, Andrea Name Colado
AU  - Simao ANC
AD  - Department of Pathology, Clinical Analysis, and Toxicology, Health Sciences 
      Center, University Hospital, State University of Londrina, Av. Robert Koch 60, 
      Vila Operaria, CEP 86038-350, Londrina, Parana, Brazil. deianame@yahoo.com.br.
LA  - eng
PT  - Journal Article
DEP - 20160330
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Albumins)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Albumins/*metabolism
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Inflammation/blood/pathology
MH  - Logistic Models
MH  - Male
MH  - Multiple Sclerosis, Chronic Progressive/blood/*diagnosis
MH  - Multiple Sclerosis, Relapsing-Remitting/blood/*diagnosis
MH  - Nitrosation
MH  - Oxidation-Reduction
MH  - Oxidative Stress
OTO - NOTNLM
OT  - Clinical forms
OT  - Inflammation
OT  - Multiple sclerosis
OT  - Nitrosative stress
OT  - Oxidative stress
EDAT- 2016/03/31 06:00
MHDA- 2017/07/08 06:00
CRDT- 2016/03/31 06:00
PHST- 2015/11/19 00:00 [received]
PHST- 2016/03/17 00:00 [accepted]
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2017/07/08 06:00 [medline]
PHST- 2016/03/31 06:00 [entrez]
AID - 10.1007/s12035-016-9860-z [pii]
AID - 10.1007/s12035-016-9860-z [doi]
PST - ppublish
SO  - Mol Neurobiol. 2017 May;54(4):2961-2968. doi: 10.1007/s12035-016-9860-z. Epub 
      2016 Mar 30.