PMID- 27026599
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 917
DP  - 2016 Apr 21
TI  - Tandem air-agitated liquid-liquid microextraction as an efficient method for 
      determination of acidic drugs in complicated matrices.
PG  - 44-52
LID - S0003-2670(16)30303-8 [pii]
LID - 10.1016/j.aca.2016.03.005 [doi]
AB  - A rapid and simple microextraction method with a high sample clean-up, termed as 
      tandem air-agitated liquid-liquid microextraction (TAALLME), is described. This 
      method is based upon the tandem implementation of the air-agitated liquid-liquid 
      microextraction (AALLME), and this approach improves the applicability of the 
      dispersive liquid-liquid microextraction (DLLME) methods in complicated matrices. 
      With very simple tools, the three non-steroidal anti-inflammatory drugs 
      diclofenac, ibuprofen, and mefenamic acid were efficiently extracted, with an 
      overall extraction time of 7 min. By performing the first AALLME, these acidic 
      analytes, contained in an aqueous sample solution (donor phase, 8.0 mL), were 
      extracted into the organic solvent (1,2-dichloroethane, 37 muL), and their simple 
      back-extraction into the aqueous acceptor solution (pH, 10.01, 51 muL) was 
      obtained in 2 min by a second implementation of AALLME. Response surface 
      methodology (RSM) was used for optimization of the experimental parameters. The 
      pH values 2.94 and 10.01 were obtained for the donor and acceptor phases, 
      respectively, and the volumes 99.5 and 51 muL were obtained for the organic 
      solvent and the acceptor phase, respectively, as the optimal extraction 
      conditions. Under the optimized conditions, tandem AALLME-HPLC-UV provided a good 
      linearity in the range of 0.5-4000 ng mL(-1), limits of detection 
      (0.1-0.3 ng mL(-1)), extraction repeatabilities (relative standard deviations 
      (RSDs) below 7.7%, n = 5), and the enrichment factors (EFs) of 80-104. Finally, 
      the applicability of the proposed method was evaluated by the extraction and 
      determination of the drugs under study in the wastewater and human plasma 
      samples.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Bazregar, Mohammad
AU  - Bazregar M
AD  - Department of Chemistry, Semnan University, Semnan 2333383-193, Iran.
FAU - Rajabi, Maryam
AU  - Rajabi M
AD  - Department of Chemistry, Semnan University, Semnan 2333383-193, Iran. Electronic 
      address: mrajabi@semnan.ac.ir.
FAU - Yamini, Yadollah
AU  - Yamini Y
AD  - Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, 
      Iran.
FAU - Asghari, Alireza
AU  - Asghari A
AD  - Department of Chemistry, Semnan University, Semnan 2333383-193, Iran.
FAU - Hemmati, Maryam
AU  - Hemmati M
AD  - Department of Chemistry, Semnan University, Semnan 2333383-193, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160310
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Acids)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Acids/*chemistry
MH  - Anti-Inflammatory Agents, Non-Steroidal/*analysis
MH  - Liquid Phase Microextraction/*methods
OTO - NOTNLM
OT  - Air-agitated liquid-liquid microextraction
OT  - Complicated matrices
OT  - Non-steroidal anti-inflammatory drugs (NSAIDs)
OT  - Tandem air-agitated liquid-liquid microextraction (TAALLME)
EDAT- 2016/03/31 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/31 06:00
PHST- 2015/10/24 00:00 [received]
PHST- 2016/03/03 00:00 [revised]
PHST- 2016/03/05 00:00 [accepted]
PHST- 2016/03/31 06:00 [entrez]
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0003-2670(16)30303-8 [pii]
AID - 10.1016/j.aca.2016.03.005 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2016 Apr 21;917:44-52. doi: 10.1016/j.aca.2016.03.005. Epub 2016 
      Mar 10.