PMID- 27028001
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20181202
IS  - 1365-3024 (Electronic)
IS  - 0141-9838 (Linking)
VI  - 38
IP  - 6
DP  - 2016 Jun
TI  - PyMIF enhances the inflammatory response in a rodent model by stimulating 
      CD11b(+) Ly6C(+) cells accumulation in spleen.
PG  - 377-83
LID - 10.1111/pim.12320 [doi]
AB  - Macrophage migration inhibitory factor (PMIF) expressed by Plasmodium parasites 
      has been proved to be similar to the mammalian MIF in both structure and 
      biological activity and is a critical upstream regulator in antimalaria innate 
      immunity. In this work, using a genetically modified (MIF-KO) strain of highly 
      lethal rodent Plasmodium yoelii 17XL (Py17XL), we found that PyMIF could increase 
      the secretion of pro-inflammatory factors by eliciting the CD11b(+) Ly6C(+) cells 
      accumulated in the spleen of infected mouse. In addition, the chemotactic effect 
      of PyMIF was demonstrated to associate with cell receptors CXCR2, CXCR4 and the 
      cell surface markers ICAM-1, LFA-4.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Liu, J
AU  - Liu J
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Shao, D
AU  - Shao D
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Lin, Y
AU  - Lin Y
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Luo, M
AU  - Luo M
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Wang, Z
AU  - Wang Z
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Yao, M
AU  - Yao M
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Hao, X
AU  - Hao X
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Wei, C
AU  - Wei C
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Gao, Y
AU  - Gao Y
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Deng, W
AU  - Deng W
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
FAU - Wang, H
AU  - Wang H
AD  - Laboratory of Parasitology, Institute of Basic Medical Sciences / Institute of 
      Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) and Peking Union 
      Medical College (PUMC), Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Parasite Immunol
JT  - Parasite immunology
JID - 7910948
RN  - 0 (Antigens, Ly)
RN  - 0 (CD11b Antigen)
RN  - 0 (CXCR4 protein, mouse)
RN  - 0 (Ly-6C antigen, mouse)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
RN  - 0 (Protozoan Proteins)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (Receptors, Interleukin-8B)
SB  - IM
MH  - Animals
MH  - Antigens, Ly/*immunology
MH  - CD11b Antigen/*immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Immunity, Innate
MH  - Macrophage Migration-Inhibitory Factors/*immunology
MH  - Malaria/*immunology/parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plasmodium yoelii/*immunology/physiology
MH  - Protozoan Proteins/*immunology
MH  - Receptors, CXCR4/immunology
MH  - Receptors, Interleukin-8B/immunology
MH  - Spleen/*immunology/parasitology
OTO - NOTNLM
OT  - immunological terms
OT  - malaria
EDAT- 2016/03/31 06:00
MHDA- 2017/03/30 06:00
CRDT- 2016/03/31 06:00
PHST- 2015/11/15 00:00 [received]
PHST- 2016/03/24 00:00 [accepted]
PHST- 2016/03/31 06:00 [entrez]
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
AID - 10.1111/pim.12320 [doi]
PST - ppublish
SO  - Parasite Immunol. 2016 Jun;38(6):377-83. doi: 10.1111/pim.12320.