PMID- 27028902
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20231213
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Print)
IS  - 0955-8810 (Linking)
VI  - 27
IP  - 6
DP  - 2016 Sep
TI  - Locomotor, discriminative stimulus, and place conditioning effects of MDAI in 
      rodents.
PG  - 497-505
LID - 10.1097/FBP.0000000000000237 [doi]
AB  - 5,6-Methylenedioxy-2-aminoindane (MDAI) has become a common substitute for 
      (+/-)-3,4-methylenedioxymethamphetamine (MDMA) in Ecstasy. MDAI is known to produce 
      MDMA-like discriminative stimulus effects, but it is not known whether MDAI has 
      psychostimulant or hallucinogen-like effects. MDAI was tested for locomotor 
      stimulant effects in mice and subsequently for discriminative stimulus effects in 
      rats trained to discriminate cocaine (10 mg/kg, intraperitoneally), 
      methamphetamine (1 mg/kg, intraperitoneally), +/-MDMA (1.5 mg/kg, 
      intraperitoneally), or (-)-2,5-dimethoxy-4-methylamphetamine hydrochloride 
      (0.5 mg/kg, intraperitoneally) from saline. The ability of MDAI to produce 
      conditioned place preference was also tested in mice. MDAI (3 to 30 mg/kg) 
      depressed locomotor activity from 10 to 60 min. A rebound stimulant effect was 
      observed at 1 to 3.5 h following 30 mg/kg. Lethality occurred in 8/8 mice 
      following 100 mg/kg MDAI. Similarly, MDMA depressed locomotor activity 
      immediately following the administration of 0.25 mg/kg and stimulant effects were 
      observed 50-70 min following the administration of 0.5 and 1 mg/kg. MDAI fully 
      substituted for the discriminative stimulus effects of MDMA (2.5 mg/kg), 
      (-)-2,5-dimethoxy-4-methylamphetamine hydrochloride (5 mg/kg), and cocaine 
      (7.5 mg/kg), but produced only 73% methamphetamine-appropriate responding at a 
      dose that suppressed responding (7.5 mg/kg). MDAI produced tremors at 10 mg/kg in 
      one methamphetamine-trained rat. MDAI produced conditioned place preference from 
      0.3 to 10 mg/kg. The effects of MDAI on locomotor activity and drug 
      discrimination were similar to those produced by MDMA, having both 
      psychostimulant-like and hallucinogen-like effects; thus, MDAI may have similar 
      abuse potential as MDMA.
FAU - Gatch, Michael B
AU  - Gatch MB
AD  - Department of Pharmacology & Neuroscience, University of North Texas Health 
      Science Center, Fort Worth, Texas, USA.
FAU - Dolan, Sean B
AU  - Dolan SB
FAU - Forster, Michael J
AU  - Forster MJ
LA  - eng
GR  - HHSN271201300001C/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 0 (Indans)
RN  - 0DMJ6G3XBF (5,6-methylenedioxy-2-aminoindane)
RN  - 15588-95-1 (DOM 2,5-Dimethoxy-4-Methylamphetamine)
RN  - 44RAL3456C (Methamphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - DOM 2,5-Dimethoxy-4-Methylamphetamine/pharmacology
MH  - Animals
MH  - Central Nervous System Stimulants/pharmacology
MH  - Cocaine/pharmacology
MH  - Conditioning, Psychological/drug effects
MH  - Discrimination Learning/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/*pharmacology
MH  - Indans/*pharmacology
MH  - Locomotion/*drug effects
MH  - Male
MH  - Methamphetamine/pharmacology
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC4965292
MID - NIHMS766774
EDAT- 2016/03/31 06:00
MHDA- 2017/11/29 06:00
PMCR- 2017/09/01
CRDT- 2016/03/31 06:00
PHST- 2016/03/31 06:00 [entrez]
PHST- 2016/03/31 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 10.1097/FBP.0000000000000237 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2016 Sep;27(6):497-505. doi: 10.1097/FBP.0000000000000237.