PMID- 27029510
OWN - NLM
STAT- MEDLINE
DCOM- 20161226
LR  - 20230108
IS  - 1873-4030 (Electronic)
IS  - 1350-4533 (Linking)
VI  - 38
IP  - 5
DP  - 2016 May
TI  - An external portable device for adaptive deep brain stimulation (aDBS) clinical 
      research in advanced Parkinson's Disease.
PG  - 498-505
LID - S1350-4533(16)30001-7 [pii]
LID - 10.1016/j.medengphy.2016.02.007 [doi]
AB  - Compared to conventional deep brain stimulation (DBS) for patients with 
      Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating 
      stimulation on the basis of the patient's clinical state, promises to achieve 
      better clinical outcomes, avoid adverse-effects and save time for tuning 
      parameters. A remaining challenge before aDBS comes into practical use is to 
      prove its feasibility and its effectiveness in larger groups of patients and in 
      more ecological conditions. We developed an external portable aDBS system 
      prototype designed for clinical testing in freely-moving PD patients with 
      externalized DBS electrodes. From a single-channel bipolar artifact-free 
      recording, it analyses local field potentials (LFPs), during ongoing DBS for 
      tuning stimulation parameters, independent from the specific feedback algorithm 
      implemented. We validated the aDBS system in vitro, by testing both its sensing 
      and closed-loop stimulation capabilities, and then tested it in vivo, focusing on 
      the sensing capabilities. By applying the aDBS system prototype in a patient with 
      PD, we provided evidence that it can track levodopa and DBS-induced LFP spectral 
      power changes among different patient's clinical states. Our system, intended for 
      testing LFP-based feedback strategies for aDBS, should help understanding how and 
      whether aDBS therapy works in PD and indicating future technical and clinical 
      advances.
CI  - Copyright (c) 2016 IPEM. Published by Elsevier Ltd. All rights reserved.
FAU - Arlotti, Mattia
AU  - Arlotti M
AD  - Clinical Center for Neurostimulation, Neurotechnology, and Movement Disorders, 
      Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 
      Department of Electronics, Computer Science and Systems, University of Bologna, 
      Cesena, Italy. Electronic address: mattia.arlotti@policlinico.mi.it.
FAU - Rossi, Lorenzo
AU  - Rossi L
AD  - Newronika s.r.l., Milano, Italy. Electronic address: lorenzo.rossi@newronika.com.
FAU - Rosa, Manuela
AU  - Rosa M
AD  - Clinical Center for Neurostimulation, Neurotechnology, and Movement Disorders, 
      Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 
      Electronic address: manuela.rosa@policlinico.mi.it.
FAU - Marceglia, Sara
AU  - Marceglia S
AD  - Clinical Center for Neurostimulation, Neurotechnology, and Movement Disorders, 
      Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 
      Department of Engineering and Architecture, University of Trieste, Trieste, 
      Italy. Electronic address: smarceglia@units.it.
FAU - Priori, Alberto
AU  - Priori A
AD  - Clinical Center for Neurostimulation, Neurotechnology, and Movement Disorders, 
      Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 
      Department of Health Sciences, University of Milan, Ospedale San Paolo, Milan, 
      Italy. Electronic address: alberto.priori@unimi.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160327
PL  - England
TA  - Med Eng Phys
JT  - Medical engineering & physics
JID - 9422753
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Deep Brain Stimulation/*instrumentation
MH  - Electrophysiological Phenomena/drug effects
MH  - Equipment Design
MH  - Humans
MH  - Levodopa/pharmacology
MH  - Parkinson Disease/physiopathology/*therapy
MH  - Time Factors
OTO - NOTNLM
OT  - Adaptive deep brain stimulation
OT  - Closed loop stimulation
OT  - Local field potentials
OT  - Parkinson's Disease
EDAT- 2016/04/01 06:00
MHDA- 2016/12/27 06:00
CRDT- 2016/04/01 06:00
PHST- 2015/05/11 00:00 [received]
PHST- 2015/12/14 00:00 [revised]
PHST- 2016/02/22 00:00 [accepted]
PHST- 2016/04/01 06:00 [entrez]
PHST- 2016/04/01 06:00 [pubmed]
PHST- 2016/12/27 06:00 [medline]
AID - S1350-4533(16)30001-7 [pii]
AID - 10.1016/j.medengphy.2016.02.007 [doi]
PST - ppublish
SO  - Med Eng Phys. 2016 May;38(5):498-505. doi: 10.1016/j.medengphy.2016.02.007. Epub 
      2016 Mar 27.