PMID- 27029911
OWN - NLM
STAT- MEDLINE
DCOM- 20170609
LR  - 20220716
IS  - 1469-4409 (Electronic)
IS  - 0950-2688 (Print)
IS  - 0950-2688 (Linking)
VI  - 144
IP  - 7
DP  - 2016 May
TI  - Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015.
PG  - 1473-81
LID - 10.1017/S0950268815003003 [doi]
AB  - The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in 
      scale, and Sierra Leone is the most severely affected country. The case fatality 
      risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the 
      severity of infections in confirmed and probable EVD cases in Sierra Leone. 
      Proportional hazards regression models were used to investigate factors 
      associated with the risk of death in EVD cases. In total, there were 17 318 EVD 
      cases reported in Sierra Leone from 23 May 2014 to 31 January 2015. Of the 
      probable and confirmed EVD cases with a reported final outcome, a total of 2536 
      deaths and 886 recoveries were reported. CFR and HFR estimates were 74.2% [95% 
      credibility interval (CrI) 72.6-75.5] and 68.9% (95% CrI 66.2-71.6), 
      respectively. Risks of death were higher in the youngest (0-4 years) and oldest 
      (⩾60 years) age groups, and in the calendar month of October 2014. Sex and 
      occupational status did not significantly affect the mortality of EVD. The CFR 
      and HFR estimates of EVD were very high in Sierra Leone.
FAU - Wong, J Y
AU  - Wong JY
AD  - WHO Collaborating Centre for Infectious Disease Epidemiology and Control,School 
      of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong 
      Kong,Hong Kong Special Administrative Region,China.
FAU - Zhang, W
AU  - Zhang W
AD  - Beijing Institute of Disease Control and Prevention,Beijing,China.
FAU - Kargbo, D
AU  - Kargbo D
AD  - Ministry of Health and Sanitation,Freetown,Sierra Leone.
FAU - Haque, U
AU  - Haque U
AD  - Emerging Pathogens Institute,University of Florida,Gainesville,FL,USA.
FAU - Hu, W
AU  - Hu W
AD  - School of Public Health and Social Work,Queensland University of 
      Technology,Brisbane,Australia.
FAU - Wu, P
AU  - Wu P
AD  - WHO Collaborating Centre for Infectious Disease Epidemiology and Control,School 
      of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong 
      Kong,Hong Kong Special Administrative Region,China.
FAU - Kamara, A
AU  - Kamara A
AD  - Ministry of Health and Sanitation,Freetown,Sierra Leone.
FAU - Chen, Y
AU  - Chen Y
AD  - Beijing Institute of Disease Control and Prevention,Beijing,China.
FAU - Kargbo, B
AU  - Kargbo B
AD  - Ministry of Health and Sanitation,Freetown,Sierra Leone.
FAU - Glass, G E
AU  - Glass GE
AD  - Emerging Pathogens Institute,University of Florida,Gainesville,FL,USA.
FAU - Yang, R
AU  - Yang R
AD  - China Mobile Laboratory Response Team for Ebola in Sierra Leone,Freetown,Sierra 
      Leone.
FAU - Cowling, B J
AU  - Cowling BJ
AD  - WHO Collaborating Centre for Infectious Disease Epidemiology and Control,School 
      of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong 
      Kong,Hong Kong Special Administrative Region,China.
FAU - Liu, C
AU  - Liu C
AD  - Beijing Institute of Disease Control and Prevention,Beijing,China.
LA  - eng
GR  - U54 GM088558/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Epidemiol Infect
JT  - Epidemiology and infection
JID - 8703737
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Ebolavirus/*physiology
MH  - *Epidemics
MH  - Female
MH  - Hemorrhagic Fever, Ebola/*mortality/virology
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Risk Assessment
MH  - *Severity of Illness Index
MH  - Sierra Leone/epidemiology
MH  - Young Adult
PMC - PMC5528867
MID - NIHMS881046
OTO - NOTNLM
OT  - Death
OT  - Ebola virus
OT  - severity
EDAT- 2016/04/01 06:00
MHDA- 2017/06/10 06:00
PMCR- 2022/05/30
CRDT- 2016/04/01 06:00
PHST- 2016/04/01 06:00 [entrez]
PHST- 2016/04/01 06:00 [pubmed]
PHST- 2017/06/10 06:00 [medline]
PHST- 2022/05/30 00:00 [pmc-release]
AID - S0950268815003003 [pii]
AID - 00300 [pii]
AID - 10.1017/S0950268815003003 [doi]
PST - ppublish
SO  - Epidemiol Infect. 2016 May;144(7):1473-81. doi: 10.1017/S0950268815003003.