PMID- 27030155
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160811
LR  - 20160331
IS  - 2352-3026 (Electronic)
IS  - 2352-3026 (Linking)
VI  - 1
IP  - 2
DP  - 2014 Nov
TI  - HLA match likelihoods for Indian patients seeking unrelated donor transplantation 
      grafts: a population-based study.
PG  - e57-63
LID - S2352-3026(14)70021-3 [pii]
LID - 10.1016/S2352-3026(14)70021-3 [doi]
AB  - BACKGROUND: For patients who do not have a suitable human leukocyte antigen 
      (HLA)-matched family donor, unrelated donor registries of adult volunteers and 
      banked umbilical cord blood (UCB) units provide the potential for successful 
      haemopoietic stem-cell transplantation. The size and genetic composition of such 
      registries determines the proportion of patients who will be able to find a 
      suitable match. We aimed to assess the proportion of positive matches for Indian 
      patients. METHODS: Using HLA data from ten existing donor and UCB registries and 
      clinical transplant centres in India, we built population-based genetic models 
      for 14 Indian regions to model Indian registry growth to predict the likelihood 
      of identifying a suitable donor-either an adult donor or UCB-for Indian patients. 
      We computed ranking tables of the top ten haplotypes in each regional group and 
      compared these with four US samples from the National Marrow Donor Program (NMDP) 
      registry. FINDINGS: The mean proportion of individuals who would have a 10/10 
      adult donor match within India ranged from 14.4% with a registry size of 25 000 
      to 60.6% with a registry size of 1 000 000. Only when donor registries increased 
      to 250 000 did the match rate within India exceed that found by searching the 
      US-NMDP registry combined with an Indian registry of 25 000 donors. The 
      proportion of matches increased logarithmically with increased registry size 
      (R(2)=0.993). For a UCB registry size of 25 000, 96.4% of individuals would find 
      a 4/6 match; however, only 18.3% would have a 6/6 match. INTERPRETATION: Serial 
      match modelling and follow-up comparisons can identify the relative and 
      progressively greater value of an India-based donor registry and UCB banking 
      network to serve the Indian population. Understanding regional HLA haplotype 
      diversity could guide registry growth and maximise benefit to patients. Similar 
      modelling could guide planning for the needs of other ethnically distinct 
      populations. FUNDING: University of Minnesota and the Indian Council for Medical 
      Research.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Maiers, Martin
AU  - Maiers M
AD  - National Marrow Donor Program, Minneapolis, MN, USA. Electronic address: 
      mmaiers@nmdp.org.
FAU - Halagan, Michael
AU  - Halagan M
AD  - National Marrow Donor Program, Minneapolis, MN, USA.
FAU - Joshi, Sangeeta
AU  - Joshi S
AD  - Manipal Hospital, Bangalore, India.
FAU - Ballal, H Sudarshan
AU  - Ballal HS
AD  - Manipal Hospital, Bangalore, India.
FAU - Jagannatthan, Latha
AU  - Jagannatthan L
AD  - Rotary Bangalore-TTK Blood Bank, Bangalore Medical Services Trust, Bangalore, 
      India.
FAU - Damodar, Sharat
AU  - Damodar S
AD  - Narayana Hrudayalaya, Bangalore, India.
FAU - Srinivasan, Periathiruvadi
AU  - Srinivasan P
AD  - Jeevan Stem Cell Bank, Chennai, India.
FAU - Narayan, Saranya
AU  - Narayan S
AD  - Jeevan Stem Cell Bank, Chennai, India.
FAU - Khattry, Navin
AU  - Khattry N
AD  - Tata Memorial Hospital, Mumbai, India.
FAU - Malhotra, Pankaj
AU  - Malhotra P
AD  - Post Graduate Institute of Medical Education and Research, Chandigarh, India.
FAU - Minz, Ranjana W
AU  - Minz RW
AD  - Post Graduate Institute of Medical Education and Research, Chandigarh, India.
FAU - Shah, Sandip A
AU  - Shah SA
AD  - Gujarat Cancer and Research Institute, Civil Hospital Campus, Ahmedabad, India.
FAU - Rajagopal, Raghu
AU  - Rajagopal R
AD  - DATRI, Chennai, India.
FAU - Cereb, Nezih
AU  - Cereb N
AD  - DATRI, Chennai, India; Histogenetics, New York, NY, USA.
FAU - Yang, Soo Young
AU  - Yang SY
AD  - DATRI, Chennai, India; Histogenetics, New York, NY, USA.
FAU - Parekh, Sunil
AU  - Parekh S
AD  - Marrow Donor Registry (India), Mumbai, India.
FAU - Mammen, Joy
AU  - Mammen J
AD  - Christian Medical College, Vellore, India.
FAU - Daniels, Dolly
AU  - Daniels D
AD  - Christian Medical College, Vellore, India.
FAU - Weisdorf, Daniel
AU  - Weisdorf D
AD  - Division of Hematology, Oncology and Transplantation, University of Minnesota, 
      MN, USA.
LA  - eng
PT  - Journal Article
DEP - 20141021
PL  - England
TA  - Lancet Haematol
JT  - The Lancet. Haematology
JID - 101643584
EDAT- 2014/11/01 00:00
MHDA- 2014/11/01 00:01
CRDT- 2016/04/01 06:00
PHST- 2016/04/01 06:00 [entrez]
PHST- 2014/11/01 00:00 [pubmed]
PHST- 2014/11/01 00:01 [medline]
AID - S2352-3026(14)70021-3 [pii]
AID - 10.1016/S2352-3026(14)70021-3 [doi]
PST - ppublish
SO  - Lancet Haematol. 2014 Nov;1(2):e57-63. doi: 10.1016/S2352-3026(14)70021-3. Epub 
      2014 Oct 21.