PMID- 27031327
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20180131
IS  - 1477-0539 (Electronic)
IS  - 1477-0520 (Linking)
VI  - 14
IP  - 24
DP  - 2016 Jun 15
TI  - Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for 
      chemokine binding.
PG  - 5652-8
LID - 10.1039/c6ob00270f [doi]
AB  - The movement of leukocytes to the site of inflammation in response to injury or 
      infection is orchestrated by chemokines binding and signaling through cognate 
      receptors. The interaction between sulfated tyrosine residues on the flexible 
      N-terminal tail of the receptor with positively charged regions of the chemokine 
      is one of the key recognition features that facilitates binding. In this 
      manuscript we describe the synthesis of polymers and silica nanoparticles bearing 
      polystyrene sulfonate brushes to mimic the sulfated tyrosine residues. We show 
      that both the polymers and nanoparticles possess high binding affinity for the 
      chemokine monocyte chemoattractant protein-1 (MCP-1) in monomeric and dimeric 
      form. We also demonstrate key differences in the relative affinity for the 
      chemokine for the free polymer versus the polymer-derived nanoparticle system.
FAU - Isahak, Naatasha
AU  - Isahak N
AD  - School of Chemistry, The University of Sydney, New South Wales 2006, Australia. 
      richard.payne@sydney.edu.au.
FAU - Sanchez, Julie
AU  - Sanchez J
AD  - Department of Biochemistry and Molecular Biology, Monash University, Melbourne, 
      Victoria, Australia.
FAU - Perrier, Sebastien
AU  - Perrier S
AD  - School of Chemistry, The University of Sydney, New South Wales 2006, Australia. 
      richard.payne@sydney.edu.au and Department of Chemistry, University of Warwick, 
      Coventry, CV4 7AL, UK and Faculty of Pharmacy and Pharmaceutical Sciences, Monash 
      University, 381 Royal Parade, Parkville, VIC 3052, Australia.
FAU - Stone, Martin J
AU  - Stone MJ
AD  - Department of Biochemistry and Molecular Biology, Monash University, Melbourne, 
      Victoria, Australia.
FAU - Payne, Richard J
AU  - Payne RJ
AD  - School of Chemistry, The University of Sydney, New South Wales 2006, Australia. 
      richard.payne@sydney.edu.au.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Org Biomol Chem
JT  - Organic & biomolecular chemistry
JID - 101154995
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Polystyrenes)
RN  - 70KO0R01RY (polystyrene sulfonic acid)
SB  - IM
MH  - Binding Sites
MH  - Chemokine CCL2/*chemistry
MH  - Humans
MH  - Molecular Structure
MH  - Nanoparticles/*chemistry
MH  - Polystyrenes/*chemical synthesis/chemistry
EDAT- 2016/04/01 06:00
MHDA- 2018/02/01 06:00
CRDT- 2016/04/01 06:00
PHST- 2016/04/01 06:00 [entrez]
PHST- 2016/04/01 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
AID - 10.1039/c6ob00270f [doi]
PST - ppublish
SO  - Org Biomol Chem. 2016 Jun 15;14(24):5652-8. doi: 10.1039/c6ob00270f.