PMID- 27031739
OWN - NLM
STAT- MEDLINE
DCOM- 20170925
LR  - 20180109
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Linking)
VI  - 48
IP  - 8
DP  - 2016 Aug
TI  - Whole Body Periodic Acceleration Improves Muscle Recovery after Eccentric 
      Exercise.
PG  - 1485-94
LID - 10.1249/MSS.0000000000000932 [doi]
AB  - INTRODUCTION: The aim of this study was to determine whether whole body periodic 
      acceleration (pGz) could improve muscle recovery after unaccustomed eccentric 
      exercise (EE). METHODS: Downhill treadmill running was used to elicit EE-induced 
      muscle damage in mice, and pGz treatment (480 cycles per minute, 1 h.d) was 
      applied daily for 10 d after the initial EE bout (day 0). Every 2 d during the 
      pGz treatment course starting at day 0, we 1) assessed intracellular Ca and Na 
      concentrations and membrane potential (as indicators of intracellular ion 
      dysfunction) in vivo in gastrocnemius muscle from anesthetized animals and 2) 
      quantified creatine kinase (CK), tumor necrosis factor alpha (TNF-alpha), monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and interleukin-10 
      (IL-10) concentrations in plasma or muscle lysates (as indicators of muscle 
      damage and inflammation). RESULTS: EE significantly increased intracellular Ca 
      and Na, CK, TNF-alpha, MCP-1, IL-6, and IL-10, all of which peaked on day 2 with the 
      exception of IL-10 and declined slowly over 10 d of recovery. pGz treatment after 
      the EE bout mitigated ion dyshomeostasis and expedited recuperation to control 
      values after 6 d of treatment. pGz treatment also accelerated the normalization 
      of CK, TNF-alpha, MCP-1, and IL-6 while further increasing IL-10 concentrations. The 
      nitric oxide synthase inhibitor L-N-nitroarginine methyl ester, administered in 
      drinking water before and maintained throughout the treatment course, was 
      sufficient to abrogate the salutary effects of pGz after EE. CONCLUSIONS: The 
      present study demonstrates whole body periodic acceleration as an effective 
      therapeutic strategy to accelerate muscle recovery after EE-induced skeletal 
      muscle injury, as indicated by a faster normalization of all the studied 
      parameters.
FAU - Lopez, Jose Rafael
AU  - Lopez JR
AD  - 1Department of Molecular Biosciences, School of Veterinary Medicine, University 
      of California, Davis, CA; 2Department of Biophysics and Biochemistry, Venezuelan 
      Institute of Scientific Research, Caracas, VENEZUELA; 3Biomedical Research 
      Center, Mexico, MEXICO; 4Center for Molecular Studies of the Cell, School of 
      Medicine, University of Chile, Santiago, CHILE; and 5Division of Neonatology, 
      Mount Sinai Medical Center, Miami, FL.
FAU - Mijares, Alfredo
AU  - Mijares A
FAU - Kolster, Juan
AU  - Kolster J
FAU - Henriquez-Olguin, Carlos
AU  - Henriquez-Olguin C
FAU - Zhang, Rui
AU  - Zhang R
FAU - Altamirano, Francisco
AU  - Altamirano F
FAU - Adams, Jose Antonio
AU  - Adams JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Cytokines)
SB  - IM
MH  - *Acceleration
MH  - Animals
MH  - Cytokines/physiology
MH  - Inflammation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Muscle, Skeletal/*injuries/physiology
MH  - Physical Conditioning, Animal/*adverse effects
MH  - Recovery of Function
MH  - Running
EDAT- 2016/04/01 06:00
MHDA- 2017/09/26 06:00
CRDT- 2016/04/01 06:00
PHST- 2016/04/01 06:00 [entrez]
PHST- 2016/04/01 06:00 [pubmed]
PHST- 2017/09/26 06:00 [medline]
AID - 10.1249/MSS.0000000000000932 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2016 Aug;48(8):1485-94. doi: 10.1249/MSS.0000000000000932.