PMID- 27033231
OWN - NLM
STAT- MEDLINE
DCOM- 20170410
LR  - 20221207
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 44
IP  - 3
DP  - 2016 Jun
TI  - Polymorphism 2184A/G in the AGER gene is not associated with diabetic retinopathy 
      in Han Chinese patients with type 2 diabetes.
PG  - 520-8
LID - 10.1177/0300060516638990 [doi]
AB  - OBJECTIVE: To assess the association between the 2184A/G polymorphism in the 
      advanced glycosylation end product-specific receptor (AGER) gene and the 
      susceptibility to diabetic retinopathy (DR) in Han Chinese patients with type 2 
      diabetes mellitus (T2DM). METHODS: This cross-sectional genotyping study included 
      patients with T2DM with and without DR. Genotype and allele frequencies of the 
      2184A/G polymorphism were detected using polymerase chain reaction-restriction 
      fragment-length polymorphism analysis. RESULTS: This study included 943 patients 
      with T2DM (285 with DR [DR group] and 658 without DR [NDR group]). There were no 
      significant differences in age, sex, body mass index, total cholesterol, 
      high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, 
      diastolic blood pressure, glycosylated haemoglobin, fasting blood glucose, 
      postprandial 2-hour blood glucose, and triglycerides between the two groups. The 
      duration of T2DM and systolic blood pressure were significantly increased in the 
      DR group compared with the NDR group. No significant differences were found in 
      allele (A and G) and genotype (AA, AG and GG) frequencies of the 2184A/G 
      polymorphism between the two groups. CONCLUSION: The 2184A/G polymorphism in the 
      AGER gene is not associated with DR in Han Chinese patients with T2DM.
CI  - (c) The Author(s) 2016.
FAU - Li, Jian
AU  - Li J
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi Province, China Department of Endocrinology and 
      Metabolism, First People's Hospital of Xinxiang City, Xinxiang, Henan Province, 
      China.
FAU - Cai, Wei
AU  - Cai W
AD  - Department of Medical Biology, Jiangxi Medical College of Nanchang University, 
      Nanchang, Jiangxi Province, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Endocrinology and Metabolism, Third Affiliated Hospital of Ganzhou 
      Medical College, Ganzhou, Jiangxi Province, China.
FAU - Zhu, Wei-Feng
AU  - Zhu WF
AD  - Department of Biochemistry and Molecular Biology, Jiangxi Medical College of 
      Nanchang University, Nanchang, Jiangxi Province, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi Province, China.
FAU - Yue, Li-Xia
AU  - Yue LX
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi Province, China.
FAU - Zhu, Ling-Yan
AU  - Zhu LY
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi Province, China.
FAU - Xiao, Jun-Ren
AU  - Xiao JR
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi Province, China.
FAU - Liu, Jian-Ying
AU  - Liu JY
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi Province, China.
FAU - Xu, Ji-Xiong
AU  - Xu JX
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi Province, China xujx1027@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20160331
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Receptor for Advanced Glycation End Products)
SB  - IM
MH  - Asian People/*genetics
MH  - Demography
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Diabetic Retinopathy/*genetics
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptor for Advanced Glycation End Products/*genetics
PMC - PMC5536713
OTO - NOTNLM
OT  - 2184A/G
OT  - Han Chinese
OT  - Receptor for advanced glycation end-products (RAGE)
OT  - diabetic retinopathy
OT  - gene polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2016/04/02 06:00
MHDA- 2017/04/11 06:00
PMCR- 2016/06/01
CRDT- 2016/04/02 06:00
PHST- 2015/10/27 00:00 [received]
PHST- 2016/02/23 00:00 [accepted]
PHST- 2016/04/02 06:00 [entrez]
PHST- 2016/04/02 06:00 [pubmed]
PHST- 2017/04/11 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - 0300060516638990 [pii]
AID - 10.1177_0300060516638990 [pii]
AID - 10.1177/0300060516638990 [doi]
PST - ppublish
SO  - J Int Med Res. 2016 Jun;44(3):520-8. doi: 10.1177/0300060516638990. Epub 2016 Mar 
      31.