PMID- 27034607
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160401
LR  - 20220321
IS  - 0976-4836 (Print)
IS  - 0974-8490 (Electronic)
IS  - 0974-8490 (Linking)
VI  - 8
IP  - 2
DP  - 2016 Apr-Jun
TI  - Standardization of Unani Antidiabetic Tablet - Qurse Tabasheer.
PG  - 147-52
LID - 10.4103/0974-8490.175611 [doi]
AB  - BACKGROUND: Quality control of Unani polyherbal formulations is the need of the 
      day for better acceptance of Unani medicine. Qurse Tabasheer (QT) is a Unani 
      polyherbal formulation containing six ingredients, Tabasheer (Siliceous 
      concretions) (Bambosa arundinaceae Retz.), Gule Surkh (Rosa damascena Mill. 
      flower), Gulnar (Punica granatum Linn. flower), Tukhme kahu (Lactuca sativa Linn. 
      seed), Tukhme khurfa (Portulaca oleraceae Linn. seed), and Gile Armani (bole) 
      widely used in treatment of diabetes. The present study was taken up to 
      scientifically evaluate the various physicochemical parameters to standardize the 
      formulation. OBJECTIVE: To evaluate various physicochemical parameters including 
      ash values, moisture content, extractive values, thin layer chromatography (TLC) 
      and high-performance TLC (HPTLC), friability, disintegration, uniformity, and 
      weight variation for standardization of QT. MATERIALS AND METHODS: Ingredients 
      were identified by the experts. The method mentioned in national formulary of 
      Unani Medicine with modification was followed for preparation of the tablets. 
      Physicochemical standards were established for ideal batch of tablets on the 
      basis of set parameters regarding friability, hardness, and disintegration. 
      Various parameters such as organoleptic characters, extractive values for the 
      extract and HPTLC fingerprinting postcompression were carried out for evaluation 
      of QT. RESULTS: Parameters for loss of weight on drying, pH, ash values, 
      extractive values documented. Qualitative chemical tests indicated the presence 
      of alkaloid, glycoside, tannins, and steroids. TLC and HPTLC fingerprinting 
      studies showing the presence of major peaks were documented. Friability, 
      hardness, and disintegration time of ideal batch was 0.09 +/- 0.0057, 4.03 +/- 0.087, 
      and 25.57 +/- 0.4860 min, respectively, and it was found to be within the set 
      limit. Weight variation was <5%. Total fungal and bacterial counts were found to 
      be within the limit. CONCLUSION: Standards were established for poly herbal 
      formulation QT, which may be used as reference for preparation and 
      standardization of QT. SUMMARY: In this work Standardization of anti-diabetic 
      tablet Qurse Tabasheer with diverse ingredients including herbal and mineral 
      origin drugs has been attempted with identification of its ingredients, 
      formulation, physicochemical evaluation and HPTLC finger printing, which may help 
      in preparing consistent and better efficacious formulations. Abbreviations Used: 
      QT: Qurse Tabasheer TLC: thin layer chromatography HPTLC: high-performance thin 
      layer chromatography WHO: World health organization FRLHT: Foundation for 
      Revitalization of Local Health Traditions Fe2O3: Iron oxide Sio2: Silica CaCo3: 
      Calcium carbonate, Tio2: Titanium Oxide NIUM: National Institute of Unani 
      Medicine #: Mesh size LOD: Loss of weight on drying USP: United state 
      Pharmacopeia UV: Ultra Violet lambda: Lambda theta: theta CFU: Colony-forming unit.
FAU - Ali, Waris
AU  - Ali W
AD  - Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani 
      Medicine, Bengaluru, Karnataka, India.
FAU - Shaikh, Hamiduddin
AU  - Shaikh H
AD  - Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani 
      Medicine, Bengaluru, Karnataka, India.
FAU - Ansari, Abdullah
AU  - Ansari A
AD  - Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani 
      Medicine, Bengaluru, Karnataka, India.
FAU - Khanam, Salma
AU  - Khanam S
AD  - Department of Pharmacognosy, Al-Ameen College of Pharmacy, Bengaluru, Karnataka, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Pharmacognosy Res
JT  - Pharmacognosy research
JID - 101558769
PMC - PMC4780142
OTO - NOTNLM
OT  - Physicochemical
OT  - Qurse Tabasheer
OT  - Unani
OT  - standardization
OT  - tablet
EDAT- 2016/04/02 06:00
MHDA- 2016/04/02 06:01
PMCR- 2016/04/01
CRDT- 2016/04/02 06:00
PHST- 2016/04/02 06:00 [entrez]
PHST- 2016/04/02 06:00 [pubmed]
PHST- 2016/04/02 06:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - PR-8-147 [pii]
AID - 10.4103/0974-8490.175611 [doi]
PST - ppublish
SO  - Pharmacognosy Res. 2016 Apr-Jun;8(2):147-52. doi: 10.4103/0974-8490.175611.