PMID- 27035469
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20240326
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 124
IP  - 9
DP  - 2016 Sep
TI  - Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated 
      Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a Native 
      American Population.
PG  - 1376-83
LID - 10.1289/ehp.1509902 [doi]
AB  - BACKGROUND: Exposure to persistent organic pollutants (POPs) is known to increase 
      risk of diabetes. OBJECTIVE: To determine which POPs are most associated with 
      prevalence of diabetes in 601 Akwesasne Native Americans. METHODS: Multiple 
      logistic regression analysis was used to assess associations between quartiles of 
      concentrations of 101 polychlorinated biphenyl (PCBs) congeners, congener groups 
      and three chlorinated pesticides [dichlorodiphenyldichloroethylene (DDE), 
      hexachlorobenzene (HCB) and mirex] with diabetes. In Model 1, the relationship 
      between quartiles of exposure and diabetes were adjusted only for sex, age, body 
      mass index (BMI), and total serum lipids. Model 2 included additional adjustment 
      for either total PCBs or total pesticides. RESULTS: Total serum PCB and pesticide 
      concentrations were each significantly associated with prevalence of diabetes 
      when adjusted only for covariates (Model 1), but neither showed a significant OR 
      for highest to lowest quartiles after additional adjustment for the other (Model 
      2). When applying Model 2 to PCB congener groups and individual pesticides, there 
      were significant omnibus differences between the four quartiles (all ps < 0.042) 
      for most groups, with the exception of penta- and hexachlorobiphenyls, DDE and 
      mirex. However, when comparing highest to lowest quartiles only non- and 
      mono-ortho PCBs [OR = 4.55 (95% CI: 1.48, 13.95)], tri- and tetrachloro PCBs [OR 
      = 3.66 (95% CI: 1.37, -9.78)] and HCB [OR = 2.64 (95% CI: 1.05, 6.61)] showed 
      significant associations with diabetes. Among the non- and mono-ortho congeners, 
      highest to lowest quartile of dioxin TEQs was not significant [OR = 1.82 (95% CI: 
      0.61, 5.40)] but the OR for the non-dioxin-like congeners was [OR = 5.01 (95% CI: 
      1.76, 14.24)]. CONCLUSION: The associations with diabetes after adjustment for 
      other POPs were strongest with the more volatile, non-dioxin-like, 
      low-chlorinated PCB congeners and HCB. Because low-chlorinated congeners are more 
      volatile, these observations suggest that inhalation of vapor-phase PCBs is an 
      important route of exposure. CITATION: Aminov Z, Haase R, Rej R, Schymura MJ, 
      Santiago-Rivera A, Morse G, DeCaprio A, Carpenter DO, and the Akwesasne Task 
      Force on the Environment. 2016. Diabetes prevalence in relation to serum 
      concentrations of polychlorinated biphenyl (PCB) congener groups and three 
      chlorinated pesticides in a Native American population. Environ Health Perspect 
      124:1376-1383; http://dx.doi.org/10.1289/ehp.1509902.
FAU - Aminov, Zafar
AU  - Aminov Z
AD  - Department of Environmental Health Sciences, School of Public Health, University 
      at Albany, State University of New York (SUNY), Rensselaer, New York, USA.
FAU - Haase, Richard
AU  - Haase R
FAU - Rej, Robert
AU  - Rej R
FAU - Schymura, Maria J
AU  - Schymura MJ
FAU - Santiago-Rivera, Azara
AU  - Santiago-Rivera A
FAU - Morse, Gayle
AU  - Morse G
FAU - DeCaprio, Anthony
AU  - DeCaprio A
FAU - Carpenter, David O
AU  - Carpenter DO
CN  - Akwesasne Task Force on the Environment
LA  - eng
GR  - P42 ES004913/ES/NIEHS NIH HHS/United States
GR  - P01 ES-04913/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160401
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diabetes Mellitus/*epidemiology
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Indians, North American
MH  - Male
MH  - Middle Aged
MH  - New York/epidemiology
MH  - Pesticides/*blood
MH  - Prevalence
MH  - Young Adult
PMC - PMC5010411
COIS- The other authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2016/04/02 06:00
MHDA- 2017/09/02 06:00
PMCR- 2016/09/01
CRDT- 2016/04/02 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/06/08 00:00 [revised]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/04/02 06:00 [entrez]
PHST- 2016/04/02 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - ehp.1509902 [pii]
AID - 10.1289/ehp.1509902 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2016 Sep;124(9):1376-83. doi: 10.1289/ehp.1509902. Epub 
      2016 Apr 1.