PMID- 27036303
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20171226
IS  - 2173-5115 (Electronic)
IS  - 0873-2159 (Linking)
VI  - 22
IP  - 5
DP  - 2016 Sep-Oct
TI  - Visceral adiposity is associated with cytokines and decrease in lung function in 
      women with persistent asthma.
PG  - 255-61
LID - S2173-5115(16)00041-5 [pii]
LID - 10.1016/j.rppnen.2016.02.005 [doi]
AB  - Abdominal obesity is associated with a risk of cardiovascular diseases, metabolic 
      syndrome and decreased lung function. However, it is not known whether asthma 
      control is influenced by the accumulation of adipose tissue in the various 
      abdominal compartments. OBJECTIVE: To determine associations among abdominal 
      adiposity distribution, asthma control, lung function and cytokines in women. 
      METHODS AND DESIGN: In this cross-sectional study of asthmatic women, data on 
      demographic variables, comorbid conditions, disease history, anthropometric and 
      spirometric measurements were collected. Subcutaneous (SAT) and visceral (VAT) 
      adipose tissues were measured by ultrasound, and the steatosis level was 
      obtained. Asthma control was assessed according to Global Initiative for Asthma 
      (GINA) criteria. Atopy was defined on the basis of allergen-specific 
      Immunoglobulin E and/or skin prick testing. Cytokine levels were determined using 
      enzyme-linked immunosorbant assays (ELISAs). RESULTS: Eighty-three asthmatic 
      women were included, 37% of whom had uncontrolled asthma. After controlling for 
      variables, a negative association between asthma control and VAT and the VAT/SAT 
      ratio was observed. VAT was negatively associated with respiratory parameters 
      after controlling for explanatory variables. In an adjusted model, body mass 
      index (BMI) and SAT were inversely associated with the adiponectin serum level 
      and VAT was associated with the interleukin 6 level. In conclusion, visceral 
      obesity was negatively associated with asthma control and lung function; and 
      positively associated with increased levels of interleukin 6 in women. We 
      hypothesize that women should be studied as a separate group, and we suggest 
      further studies with a control group to know if the uncontrolled asthmatic group 
      is directly affected by visceral adipose inflammatory markers.
CI  - Copyright (c) 2016 Sociedade Portuguesa de Pneumologia. Published by Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Capelo, A V
AU  - Capelo AV
AD  - Gaffree and Guinle Hospital from Federal University of the State of Rio de 
      Janeiro (UNIRIO), HUGG, Medical, Rua Mariz e Barros, 775, Rio de Janeiro, Rio de 
      Janeiro, Brazil. Electronic address: albertinacapelo@hotmail.com.
FAU - da Fonseca, V M
AU  - da Fonseca VM
AD  - Fernandes Figueira Institute from FIOCRUZ, IFF, Education, Av. Rui Barbosa, 716, 
      Rio de Janeiro, Rio de Janeiro 22250-020, Brazil.
FAU - Peixoto, M V M
AU  - Peixoto MV
AD  - Fernandes Figueira Institute from FIOCRUZ, IFF, Education, Av. Rui Barbosa, 716, 
      Rio de Janeiro, Rio de Janeiro 22250-020, Brazil.
FAU - de Carvalho, S R
AU  - de Carvalho SR
AD  - Gaffree and Guinle Hospital from Federal University of the State of Rio de 
      Janeiro (UNIRIO), HUGG, Medical, Rua Mariz e Barros, 775, Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Azevedo, C M
AU  - Azevedo CM
AD  - Gaffree and Guinle Hospital from Federal University of the State of Rio de 
      Janeiro (UNIRIO), HUGG, Medical, Rua Mariz e Barros, 775, Rio de Janeiro, Rio de 
      Janeiro, Brazil.
FAU - Elsas, M I G
AU  - Elsas MI
AD  - Microbiology Institute from Federal University of Rio de Janeiro (UFRJ), Rua 
      Rodolpho Paulo Roco, 255, Rio de Janeiro, Brazil.
FAU - Marques, B
AU  - Marques B
AD  - Microbiology Institute from Federal University of Rio de Janeiro (UFRJ), Rua 
      Rodolpho Paulo Roco, 255, Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160329
PL  - Spain
TA  - Rev Port Pneumol (2006)
JT  - Revista portuguesa de pneumologia
JID - 101655511
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asthma/blood/physiopathology/therapy
MH  - Cross-Sectional Studies
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - *Intra-Abdominal Fat/diagnostic imaging
MH  - Middle Aged
MH  - Ultrasonography
MH  - Young Adult
OTO - NOTNLM
OT  - Abdominal obesity
OT  - Asthma
OT  - Asthma control
OT  - Cytokines
OT  - Lung function
OT  - Woman
EDAT- 2016/04/03 06:00
MHDA- 2017/12/27 06:00
CRDT- 2016/04/03 06:00
PHST- 2015/11/21 00:00 [received]
PHST- 2016/01/18 00:00 [revised]
PHST- 2016/02/16 00:00 [accepted]
PHST- 2016/04/03 06:00 [entrez]
PHST- 2016/04/03 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
AID - S2173-5115(16)00041-5 [pii]
AID - 10.1016/j.rppnen.2016.02.005 [doi]
PST - ppublish
SO  - Rev Port Pneumol (2006). 2016 Sep-Oct;22(5):255-61. doi: 
      10.1016/j.rppnen.2016.02.005. Epub 2016 Mar 29.