PMID- 27036727
OWN - NLM
STAT- MEDLINE
DCOM- 20170105
LR  - 20190816
IS  - 2214-9996 (Electronic)
IS  - 2214-9996 (Linking)
VI  - 81
IP  - 5
DP  - 2015 Sep-Oct
TI  - Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women 
      and Children.
PG  - 689-93
LID - S2214-9996(15)01305-3 [pii]
LID - 10.1016/j.aogh.2015.12.008 [doi]
AB  - BACKGROUND: Helminth infection is an important health challenge. Because of 
      modulation of the immune response toward T-helper 2 (Th2) cells, the immunologic 
      interplay that manifest during the coexistence of helminth infection with other 
      conditions is still poorly understood. OBJECTIVE: This study determined the 
      pattern of alteration in selected cytokines and immunoglobulin E (IgE) in 
      pregnant women, preschool aged children, and school-aged children with helminth 
      infection compared with uninfected groups. METHODS: Seventeen pregnant women, 42 
      preschool-aged children, and 60 school-aged children with helminth infection (HI) 
      were recruited into this study. They were matched with 21 pregnant women, 42 
      preschool-aged children, and 50 school-aged children without helminth infection 
      (HN) who served as controls. Venous blood samples were collected from each 
      participant and analyzed for serum levels of tumor necrosis factor alpha (TNF-alpha), 
      interleukin-10 (IL-10), interleukin-8 (IL-8), interleukin-6 (IL-6), and IgE. 
      Statistical analysis was done using the Student t test, and P < .05 was 
      considered as statistically significant. FINDINGS: Only serum level of IgE was 
      significantly elevated in HI pregnant women compared with HN pregnant women. In 
      HI preschool- and school-aged children, serum levels of IL-8, IL-6, and IgE were 
      significantly elevated compared with HN children. However, preschool- and 
      school-aged children with HI had similar levels of serum TNF-alpha and IL-10 compared 
      with their corresponding HN groups. CONCLUSIONS: It could be concluded that 
      altered cytokines expression in children and pregnant women with helminth 
      infection might have some implications on need for deworming programs to improve 
      pregnancy outcomes and vaccine responses.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Arinola, Ganiyu Olatunbosun
AU  - Arinola GO
AD  - Department of Chemical Pathology, College of Medicine, University of Ibadan, 
      Ibadan, Nigeria. Electronic address: drarinolaog64@yahoo.com.
FAU - Morenikeji, Olajumoke Abimbola
AU  - Morenikeji OA
AD  - Department of Zoology, University of Ibadan, Ibadan, Nigeria.
FAU - Akinwande, Kazeem Sanjo
AU  - Akinwande KS
AD  - Department of Chemical Pathology, College of Medicine, University of Ibadan, 
      Ibadan, Nigeria.
FAU - Alade, Ayodele Olasoji
AU  - Alade AO
AD  - Department of Zoology, University of Ibadan, Ibadan, Nigeria.
FAU - Olateru-Olagbegi, Oluwakemi
AU  - Olateru-Olagbegi O
AD  - Department of Chemical Pathology, College of Medicine, University of Ibadan, 
      Ibadan, Nigeria.
FAU - Alabi, Ponmile Emmanuel
AU  - Alabi PE
AD  - Department of Zoology, University of Ibadan, Ibadan, Nigeria.
FAU - Rahamon, Sheu Kadiri
AU  - Rahamon SK
AD  - Department of Chemical Pathology, College of Medicine, University of Ibadan, 
      Ibadan, Nigeria.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Glob Health
JT  - Annals of global health
JID - 101620864
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*immunology
MH  - Female
MH  - Helminthiasis/*immunology
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Interleukin-10/immunology
MH  - Interleukin-6/immunology
MH  - Interleukin-8/immunology
MH  - Male
MH  - Nigeria
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/*immunology
MH  - Tumor Necrosis Factor-alpha/immunology
OTO - NOTNLM
OT  - IgE
OT  - children
OT  - cytokines
OT  - helminth infection
OT  - pregnant women
EDAT- 2016/04/03 06:00
MHDA- 2017/01/06 06:00
CRDT- 2016/04/03 06:00
PHST- 2016/04/03 06:00 [entrez]
PHST- 2016/04/03 06:00 [pubmed]
PHST- 2017/01/06 06:00 [medline]
AID - S2214-9996(15)01305-3 [pii]
AID - 10.1016/j.aogh.2015.12.008 [doi]
PST - ppublish
SO  - Ann Glob Health. 2015 Sep-Oct;81(5):689-93. doi: 10.1016/j.aogh.2015.12.008.