PMID- 27037786
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20231111
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1373
IP  - 1
DP  - 2016 Jun
TI  - Restructuring reward processing with Mindfulness-Oriented Recovery Enhancement: 
      novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, 
      stress, and pain.
PG  - 25-37
LID - 10.1111/nyas.13034 [doi]
AB  - Though valuation processes are fundamental to survival of the human species, 
      hedonic dysregulation is at the root of an array of maladies, including 
      addiction, stress, and chronic pain, as evidenced by the allostatic shift in the 
      relative salience of natural reward to drug reward observed among persons with 
      severe substance use disorders. To address this crucial problem, novel 
      interventions are needed to restore hedonic regulatory processes gone awry in 
      persons exhibiting addictive behaviors. This article describes a theoretical 
      rationale and empirical evidence for the effects of one such new intervention, 
      Mindfulness-Oriented Recovery Enhancement (MORE), on top-down and bottom-up 
      mechanisms implicated in cognitive control and hedonic regulation. MORE is 
      innovative and distinct from extant mindfulness-based interventions in that it 
      unites traditional mindfulness meditation with reappraisal and savoring 
      strategies designed to reverse the downward shift in salience of natural reward 
      relative to drug reward, representing a crucial tipping point to disrupt the 
      progression of addiction-a mechanistic target that no other behavioral 
      intervention has been designed to address. Though additional studies are needed, 
      clinical and biobehavioral data from several completed and ongoing trials suggest 
      that MORE may exert salutary effects on addictive behaviors and the 
      neurobiological processes that underpin them.
CI  - (c) 2016 New York Academy of Sciences.
FAU - Garland, Eric L
AU  - Garland EL
AD  - College of Social Work, University of Utah, and Supportive Oncology and 
      Survivorship, Huntsman Cancer Institute, Salt Lake City, Utah.
LA  - eng
GR  - R01 DA042033/DA/NIDA NIH HHS/United States
GR  - R34 DA037005/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20160401
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Behavior, Addictive/psychology/*therapy
MH  - Chronic Pain/psychology/*therapy
MH  - Humans
MH  - *Meditation
MH  - *Mindfulness
MH  - *Reward
MH  - Stress, Psychological/psychology/*therapy
MH  - Treatment Outcome
PMC - PMC4940274
MID - NIHMS756679
OTO - NOTNLM
OT  - addiction
OT  - allostasis
OT  - mindfulness
OT  - reappraisal
OT  - reward
OT  - savoring
COIS- Conflicts of interest The author declares no conflicts of interest.
EDAT- 2016/04/03 06:00
MHDA- 2017/07/25 06:00
PMCR- 2017/06/01
CRDT- 2016/04/03 06:00
PHST- 2016/04/03 06:00 [entrez]
PHST- 2016/04/03 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 10.1111/nyas.13034 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2016 Jun;1373(1):25-37. doi: 10.1111/nyas.13034. Epub 2016 Apr 
      1.