PMID- 27038109
OWN - NLM
STAT- MEDLINE
DCOM- 20171121
LR  - 20220408
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 71
IP  - 8
DP  - 2016 Aug
TI  - The Angioedema Quality of Life Questionnaire (AE-QoL) - assessment of sensitivity 
      to change and minimal clinically important difference.
PG  - 1203-9
LID - 10.1111/all.12900 [doi]
AB  - BACKGROUND: The Angioedema Quality of Life Questionnaire (AE-QoL) has recently 
      been developed and validated as the first specific patient-reported outcome tool 
      to assess quality of life (QoL) impairment in recurrent angioedema patients. As 
      of yet, its sensitivity to change and minimal clinically important difference 
      (MCID) have not been established. METHODS: Recurrent angioedema patients with 
      chronic spontaneous urticaria or hereditary angioedema were repeatedly asked to 
      complete the AE-QoL along with the SF-12 and other anchors for QoL impairment and 
      disease activity during routine care visits. The sensitivity to change of AE-QoL 
      was determined by correlating changes in its scores over time with changes in the 
      applied anchors. In addition, the MCID was determined using anchor-based and 
      distributional criterion-based approaches. RESULTS: Two hundred and seventy-eight 
      patients contributed data sets for analysis. Baseline AE-QoL values were found to 
      correlate well with SF-12 results as well as all other applied anchors for 
      angioedema-related QoL impairment and disease activity. In addition, AE-QoL score 
      changes over time correlated significantly with changes in the above anchors, 
      thus demonstrating its sensitivity to change. The MCID of the AE-QoL total score 
      was found to be six points. CONCLUSION: The AE-QoL is a valuable tool to assess 
      changes of QoL impairment in recurrent angioedema patients over time, including 
      changes due to treatment.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Weller, K
AU  - Weller K
AD  - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - 
      Universitatsmedizin Berlin, Berlin, Germany.
FAU - Magerl, M
AU  - Magerl M
AD  - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - 
      Universitatsmedizin Berlin, Berlin, Germany.
FAU - Peveling-Oberhag, A
AU  - Peveling-Oberhag A
AD  - Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
FAU - Martus, P
AU  - Martus P
AD  - Institute for Clinical Epidemiology and Applied Biometry, Eberhard-Karl 
      University Tubingen, Tubingen, Germany.
FAU - Staubach, P
AU  - Staubach P
AD  - Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
FAU - Maurer, M
AU  - Maurer M
AD  - Department of Dermatology and Allergy, Allergie-Centrum-Charite, Charite - 
      Universitatsmedizin Berlin, Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160613
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Adult
MH  - Angioedema/*epidemiology
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - *Quality of Life
MH  - Recurrence
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
MH  - Urticaria/epidemiology
OTO - NOTNLM
OT  - angioedema
OT  - minimal clinically important difference
OT  - quality of life
OT  - responsivity
OT  - sensitivity to change
EDAT- 2016/04/03 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/04/03 06:00
PHST- 2016/03/26 00:00 [accepted]
PHST- 2016/04/03 06:00 [entrez]
PHST- 2016/04/03 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1111/all.12900 [doi]
PST - ppublish
SO  - Allergy. 2016 Aug;71(8):1203-9. doi: 10.1111/all.12900. Epub 2016 Jun 13.