PMID- 27038892
OWN - NLM
STAT- MEDLINE
DCOM- 20170502
LR  - 20180814
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 166
DP  - 2016 Jun
TI  - Outer Retinal Structural Alternation and Segmentation Errors in Optical Coherence 
      Tomography Imaging in Patients With a History of Retinopathy of Prematurity.
PG  - 169-180
LID - S0002-9394(16)30134-9 [pii]
LID - 10.1016/j.ajo.2016.03.030 [doi]
AB  - PURPOSE: To evaluate retinal anatomy and segmentation errors from spectral-domain 
      optical coherence tomography (SD-OCT) imaging in school-aged children. DESIGN: A 
      prospective cohort study in a referral medical center. METHODS: One hundred 
      thirty-three eyes of 133 patients were enrolled. Patients were grouped as those 
      who were treated for retinopathy of prematurity (ROP) (ROP-Tx group); those with 
      spontaneously regressed ROP (ROP-non-Tx group); other premature patients 
      (premature group); and full-term age-matched children (full-term group). Anatomy 
      and segmentation errors of retina were evaluated by SD-OCT. RESULTS: The mean age 
      at assessment was 9.5 years (range, 4-16 years). The external limiting membrane 
      (ELM) and the cone outer segment tips (COST) line were least frequently 
      identified in patients of the ROP-Tx group (65.2% and 47.8%, P = .002 and P < 
      .001, respectively). The visual acuity of the patients did not correlate 
      significantly with the absence of COST line (P = .140) but correlated with the 
      absence of ELM (P < .001). The presence of artifacts, including misidentification 
      of the inner retina, misidentification of the outer retina, out-of-register 
      artifacts, off-center scans, and degraded scan images, was observed to range from 
      0.6% to 50.0% in 4 groups of patients. All types of errors occurred more 
      frequently in the ROP-Tx group than in the full-term group (all P < .05). 
      CONCLUSIONS: Outer retinal abnormalities were commonly observed in the ROP-Tx 
      group. The higher segmentation errors in the ROP-Tx group might be related to 
      fine structural abnormalities in the outer retina. Future studies are needed to 
      investigate the mechanisms for these structural changes.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Chen, Yi-Hsing
AU  - Chen YH
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Lien, Reyin
AU  - Lien R
AD  - Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College 
      of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chiang, Michael F
AU  - Chiang MF
AD  - Departments of Ophthalmology and Medical Informatics & Clinical Epidemiology, 
      Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
FAU - Huang, Chung-Ying
AU  - Huang CY
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chang, Chee-Jen
AU  - Chang CJ
AD  - Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, 
      Taiwan.
FAU - Wang, Nan-Kai
AU  - Wang NK
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chen, Yen-Po
AU  - Chen YP
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chao, An-Ning
AU  - Chao AN
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chen, Kuan-Jen
AU  - Chen KJ
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chen, Tun-Lu
AU  - Chen TL
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Hwang, Yih-Shiou
AU  - Hwang YS
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Lai, Chi-Chun
AU  - Lai CC
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Wu, Wei-Chi
AU  - Wu WC
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: 
      weichi666@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160330
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Artifacts
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Cryotherapy
MH  - *Diagnostic Errors
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Laser Coagulation
MH  - Male
MH  - Prospective Studies
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retinopathy of Prematurity/*diagnosis/physiopathology/therapy
MH  - Tomography, Optical Coherence/*standards
MH  - Visual Acuity/physiology
EDAT- 2016/04/04 06:00
MHDA- 2017/05/04 06:00
CRDT- 2016/04/04 06:00
PHST- 2015/11/23 00:00 [received]
PHST- 2016/03/22 00:00 [revised]
PHST- 2016/03/23 00:00 [accepted]
PHST- 2016/04/04 06:00 [entrez]
PHST- 2016/04/04 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
AID - S0002-9394(16)30134-9 [pii]
AID - 10.1016/j.ajo.2016.03.030 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2016 Jun;166:169-180. doi: 10.1016/j.ajo.2016.03.030. Epub 2016 
      Mar 30.