PMID- 27039688
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20220321
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 8
IP  - 15
DP  - 2016 Apr 20
TI  - Macrophage Cell Membrane Camouflaged Au Nanoshells for in Vivo Prolonged 
      Circulation Life and Enhanced Cancer Photothermal Therapy.
PG  - 9610-8
LID - 10.1021/acsami.6b00853 [doi]
AB  - Macrophage cell membrane (MPCM)-camouflaged gold nanoshells (AuNS) that can serve 
      as a new generation of photothermal conversion agents for in vivo photothermal 
      cancer therapy are presented. They are constructed by the fusion of biocompatible 
      AuNSs and MPCM vesicles. The resulting MPCM-coated AuNSs exhibited good colloidal 
      stability and kept the original near-infrared (NIR) adsorption of AuNSs. Because 
      AuNS carried high-density coverage of MPCMs, the totally functional portions of 
      macrophage cells membrane were grafted onto the surface of AuNSs. This surface 
      functionalization provided active targeting ability by recognizing tumor 
      endothelium and thus improved tumoritropic accumulation compared to the red blood 
      cell membrane-coating approach. These biomimetic nanoparticles significantly 
      enhance in vivo blood circulation time and local accumulation at the tumor when 
      administered systematically. Upon NIR laser irradiation, local heat generated by 
      the MPCM-coated AuNS achieves high efficiency to suppress tumor growth and 
      selectively ablate cancerous cells within the illuminated zone. Therefore, 
      MPCM-coated AuNSs remained the natural properties of their source cells, which 
      may improve the efficacy of photothermal therapy modulated by AuNSs and other 
      noble-metal nanoparticles.
FAU - Xuan, Mingjun
AU  - Xuan M
AD  - Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of 
      Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , 
      Harbin 150080, China.
AD  - Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, 
      Interface, and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy 
      of Sciences , Beijing 100190, China.
FAU - Shao, Jingxin
AU  - Shao J
AD  - Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of 
      Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , 
      Harbin 150080, China.
AD  - CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National 
      Center for Nanoscience and Technology , Beijing 100190, China.
FAU - Dai, Luru
AU  - Dai L
AD  - CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National 
      Center for Nanoscience and Technology , Beijing 100190, China.
FAU - Li, Junbai
AU  - Li J
AD  - Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, 
      Interface, and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy 
      of Sciences , Beijing 100190, China.
FAU - He, Qiang
AU  - He Q
AD  - Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of 
      Education, Micro/Nanotechnology Research Centre, Harbin Institute of Technology , 
      Harbin 150080, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160408
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Membrane/*chemistry
MH  - Flow Cytometry
MH  - Gold/*chemistry
MH  - *Hyperthermia, Induced
MH  - Macrophages/*cytology
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Nanoshells/*chemistry/ultrastructure
MH  - Neoplasms/*therapy
MH  - *Phototherapy
MH  - Time Factors
OTO - NOTNLM
OT  - Au nanoshell
OT  - biostealth coating
OT  - long circulation
OT  - macrophage cell membrane
OT  - photothermal therapy
EDAT- 2016/04/05 06:00
MHDA- 2017/01/04 06:00
CRDT- 2016/04/05 06:00
PHST- 2016/04/05 06:00 [entrez]
PHST- 2016/04/05 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
AID - 10.1021/acsami.6b00853 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2016 Apr 20;8(15):9610-8. doi: 10.1021/acsami.6b00853. 
      Epub 2016 Apr 8.