PMID- 27040276
OWN - NLM
STAT- MEDLINE
DCOM- 20180713
LR  - 20181113
IS  - 1096-3618 (Electronic)
IS  - 1044-5323 (Print)
IS  - 1044-5323 (Linking)
VI  - 27
IP  - 6
DP  - 2015 Dec
TI  - Dendritic cell development-History, advances, and open questions.
PG  - 388-96
LID - S1044-5323(16)00019-1 [pii]
LID - 10.1016/j.smim.2016.03.012 [doi]
AB  - Dendritic cells (DCs) are uniquely potent in orchestrating T cell immune 
      response, thus they are indispensable immune sentinels. They originate from 
      progenitors in the bone marrow through hematopoiesis, a highly regulated 
      developmental process involving multiple cellular and molecular events. This 
      review highlights studies of DC development-from the discovery of DCs as 
      glass-adherent antigen presenting cells to the debate and resolution of their 
      origin and lineage map. In particular, we summarize the roles of lineage-specific 
      cytokines, the placement of distinct hematopoietic progenitors within the DC 
      lineage and transcriptional programs governing DC development, which together 
      have allowed us to diagram the current view of DC hematopoiesis. Important open 
      questions and debates on the DC development and relevant models are also 
      discussed.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Puhr, Sarah
AU  - Puhr S
AD  - Columbia University Medical Center, Department of Microbiology and Immunology, 
      New York, NY 10032, USA. Electronic address: sp2911@cumc.columbia.edu.
FAU - Lee, Jaeyop
AU  - Lee J
AD  - Columbia University Medical Center, Department of Microbiology and Immunology, 
      New York, NY 10032, USA. Electronic address: jl3567@cumc.columbia.edu.
FAU - Zvezdova, Ekaterina
AU  - Zvezdova E
AD  - Columbia University Medical Center, Department of Microbiology and Immunology, 
      New York, NY 10032, USA. Electronic address: ez2229@cumc.columbia.edu.
FAU - Zhou, Yu J
AU  - Zhou YJ
AD  - Columbia University Medical Center, Department of Microbiology and Immunology, 
      New York, NY 10032, USA.
FAU - Liu, Kang
AU  - Liu K
AD  - Columbia University Medical Center, Department of Microbiology and Immunology, 
      New York, NY 10032, USA. Electronic address: kl2529@cumc.columbia.edu.
LA  - eng
GR  - F31 NS084776/NS/NINDS NIH HHS/United States
GR  - R01 AI101251/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160331
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Dendritic Cells/*cytology/immunology
MH  - Hematopoiesis
MH  - Humans
PMC - PMC5032838
MID - NIHMS774520
OTO - NOTNLM
OT  - CDP
OT  - Cytokine
OT  - Dendritic cell
OT  - Hematopoiesis
OT  - Lineage
OT  - MDP
OT  - Mononuclear phagocyte system
OT  - Pre-cDC
OT  - Progenitor
OT  - Transcription factor
EDAT- 2016/04/05 06:00
MHDA- 2016/04/05 06:01
PMCR- 2017/03/31
CRDT- 2016/04/05 06:00
PHST- 2015/09/10 00:00 [received]
PHST- 2016/03/16 00:00 [accepted]
PHST- 2016/04/05 06:00 [entrez]
PHST- 2016/04/05 06:00 [pubmed]
PHST- 2016/04/05 06:01 [medline]
PHST- 2017/03/31 00:00 [pmc-release]
AID - S1044-5323(16)00019-1 [pii]
AID - 10.1016/j.smim.2016.03.012 [doi]
PST - ppublish
SO  - Semin Immunol. 2015 Dec;27(6):388-96. doi: 10.1016/j.smim.2016.03.012. Epub 2016 
      Mar 31.