PMID- 27041159
OWN - NLM
STAT- MEDLINE
DCOM- 20160823
LR  - 20181202
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 55
IP  - 7
DP  - 2016
TI  - Pathohistological Evidence of Smoldering Inflammation in Rheumatic Heart Disease 
      with Massive Left Atrial Calcification.
PG  - 751-4
LID - 10.2169/internalmedicine.55.6125 [doi]
AB  - A 74-year-old man, who had a history of a mitral valve replacement for rheumatic 
      heart disease (RHD) 30 years previously, was admitted with progressive heart 
      failure. Massive calcification was observed around the left atrium on 
      multidetector CT, in addition to a late gadolinium enhancement (LGE)-positive 
      layer adjacently outside of the calcification on MRI. He underwent a second 
      mitral valve replacement for the prosthetic valve failure. Pathohistological 
      analyses of a tissue section of the left atrial wall from a surgical specimen 
      revealed lymphocyte and macrophage infiltration that coincided with the 
      LGE-positive layer on MRI, suggesting the existence of sustained active 
      inflammation even after the long period of RHD.
FAU - Shiba, Mikio
AU  - Shiba M
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center, Japan.
FAU - Sugano, Yasuo
AU  - Sugano Y
FAU - Ikeda, Yoshihiko
AU  - Ikeda Y
FAU - Ishibashi-Ueda, Hatsue
AU  - Ishibashi-Ueda H
FAU - Ohara, Takahiro
AU  - Ohara T
FAU - Hasegawa, Takuya
AU  - Hasegawa T
FAU - Kanzaki, Hideaki
AU  - Kanzaki H
FAU - Anzai, Toshihisa
AU  - Anzai T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160401
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Calcinosis/*pathology/physiopathology/surgery
MH  - Dyspnea/etiology/*pathology
MH  - Gadolinium
MH  - Heart Atria/pathology
MH  - Heart Failure/pathology
MH  - Heart Valve Diseases/*pathology
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Inflammation/etiology/*pathology/physiopathology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Rheumatic Heart Disease/complications/*pathology/physiopathology/surgery
MH  - Treatment Outcome
EDAT- 2016/04/05 06:00
MHDA- 2016/08/24 06:00
CRDT- 2016/04/05 06:00
PHST- 2016/04/05 06:00 [entrez]
PHST- 2016/04/05 06:00 [pubmed]
PHST- 2016/08/24 06:00 [medline]
AID - 10.2169/internalmedicine.55.6125 [doi]
PST - ppublish
SO  - Intern Med. 2016;55(7):751-4. doi: 10.2169/internalmedicine.55.6125. Epub 2016 
      Apr 1.