PMID- 27041554
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20181113
IS  - 1432-1262 (Electronic)
IS  - 0179-1958 (Print)
IS  - 0179-1958 (Linking)
VI  - 31
IP  - 5
DP  - 2016 May
TI  - Hyperbaric oxygen therapy improves colorectal anastomotic healing.
PG  - 1031-1038
LID - 10.1007/s00384-016-2573-y [doi]
AB  - PURPOSE: Hyperbaric oxygen treatment (HBOT) has been found to improve the healing 
      of poorly oxygenated tissues. This study aimed to investigate the influence of 
      HBOT on the healing in ischemic colorectal anastomosis. METHODS: Forty Wistar 
      rats were randomly divided into a treatment group that received HBOT for 10 
      consecutive days (7 days before and 3 days after surgery), or in a control group, 
      which did not receive the therapy. Colectomy with an ischemic anastomosis was 
      performed in all rats. In each group, the rats were followed for 3 or 7 days 
      after surgery to determine the influence of HBOT on anastomotic healing. RESULTS: 
      Five rats from each group died during follow-up. No anastomotic dehiscence was 
      seen in the HBOT group, compared to 37.5 % and 28.6 % dehiscence in the control 
      group on postoperative day (POD) 3 and 7, respectively. The HBOT group had a 
      significantly higher bursting pressure (130.9 +/- 17.0 mmHg) than the control group 
      (88.4 +/- 46.7 mmHg; p = 0.03) on POD 3. On POD 3 and POD 7, the adhesion severity 
      was significantly higher in the control groups than in the HBOT groups 
      (p < 0.005). Kidney function (creatinine level) of the HBOT group was 
      significantly better than of the control group on POD 7 (p = 0.001). 
      Interestingly, a significantly higher number of CD206+ cells (marker for type 2 
      macrophages) was observed in the HBOT group at the anastomotic area on POD 3. 
      CONCLUSION: Hyperbaric oxygen enhanced the healing of ischemic anastomoses in 
      rats and improved the postoperative kidney function.
FAU - Boersema, G S A
AU  - Boersema GSA
AD  - Department of Surgery, Laboratory of Experimental Surgery, Erasmus MC, University 
      Medical Center, Room Ee-173 Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
FAU - Wu, Z
AU  - Wu Z
AD  - Department of Surgery, Laboratory of Experimental Surgery, Erasmus MC, University 
      Medical Center, Room Ee-173 Postbus 2040, 3000 CA, Rotterdam, The Netherlands. 
      wuzhouqiao@gmail.com.
AD  - Department of Gastrointestinal Surgery, Peking University Cancer Hospital and 
      Institute, Beijing, China. wuzhouqiao@gmail.com.
FAU - Kroese, L F
AU  - Kroese LF
AD  - Department of Surgery, Laboratory of Experimental Surgery, Erasmus MC, University 
      Medical Center, Room Ee-173 Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
FAU - Vennix, S
AU  - Vennix S
AD  - Department of Surgery, Laboratory of Experimental Surgery, Erasmus MC, University 
      Medical Center, Room Ee-173 Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
AD  - Department of Surgery, Amsterdam Medical Center, Amsterdam, The Netherlands.
FAU - Bastiaansen-Jenniskens, Y M
AU  - Bastiaansen-Jenniskens YM
AD  - Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The 
      Netherlands.
FAU - van Neck, J W
AU  - van Neck JW
AD  - Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical 
      Center, Rotterdam, The Netherlands.
FAU - Lam, K H
AU  - Lam KH
AD  - Department of Pathology, Erasmus MC, University Medical Center, Rotterdam, The 
      Netherlands.
FAU - Kleinrensink, G J
AU  - Kleinrensink GJ
AD  - Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The 
      Netherlands.
FAU - Jeekel, J
AU  - Jeekel J
AD  - Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The 
      Netherlands.
FAU - Lange, J F
AU  - Lange JF
AD  - Department of Surgery, Laboratory of Experimental Surgery, Erasmus MC, University 
      Medical Center, Room Ee-173 Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20160404
PL  - Germany
TA  - Int J Colorectal Dis
JT  - International journal of colorectal disease
JID - 8607899
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Abdominal Abscess/blood/complications/etiology
MH  - Anastomosis, Surgical/adverse effects
MH  - Anastomotic Leak/blood/etiology
MH  - Animals
MH  - Cell Count
MH  - Colon/*surgery
MH  - Creatinine/blood
MH  - *Hyperbaric Oxygenation
MH  - Macrophages/pathology
MH  - Male
MH  - Rats, Wistar
MH  - Rectum/*surgery
MH  - Surgical Wound Dehiscence/blood/complications/etiology
MH  - Tissue Adhesions/blood/complications/pathology
MH  - *Wound Healing
PMC - PMC4834105
OTO - NOTNLM
OT  - Anastomotic healing
OT  - Animal model
OT  - Hyperbaric oxygen therapy
OT  - Perfusion
EDAT- 2016/04/05 06:00
MHDA- 2017/01/04 06:00
PMCR- 2016/04/04
CRDT- 2016/04/05 06:00
PHST- 2016/03/22 00:00 [accepted]
PHST- 2016/04/05 06:00 [entrez]
PHST- 2016/04/05 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
PHST- 2016/04/04 00:00 [pmc-release]
AID - 10.1007/s00384-016-2573-y [pii]
AID - 2573 [pii]
AID - 10.1007/s00384-016-2573-y [doi]
PST - ppublish
SO  - Int J Colorectal Dis. 2016 May;31(5):1031-1038. doi: 10.1007/s00384-016-2573-y. 
      Epub 2016 Apr 4.