PMID- 27041826
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20231213
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2016
DP  - 2016
TI  - Cytokines and Effector/Regulatory Cells Characterization in the Physiopathology 
      of Cutaneous Lupus Erythematous: A Cross-Sectional Study.
PG  - 7074829
LID - 10.1155/2016/7074829 [doi]
LID - 7074829
AB  - We compared the presence of diverse cytokines and regulatory T and B cells in 
      skin biopsies of discoid lupus erythematosus (DLE) and subacute cutaneous lupus 
      erythematosus (SCLE). We included 19 patients with DLE, 13 with SCLE, 8 healthy 
      controls, and 5 patients with hypertrophic scars. We assessed the CLASI activity 
      score. To determine IL-22-producing cells and the subpopulation of 
      CD4(+)/IL-17A(+)-, CD4(+)/IL-4(+)-, and CD4(+)/IFN-gamma (+)-expressing T cells, 
      CD123(+)/IDO(+) pDCs, CD25(+)/Foxp3(+) Tregs, and CD20(+)/IL-10(+)-producing B 
      cells, an immunostaining procedure was performed. Also intracellular IL-22, 
      IL-17, IL-4, IFN-gamma, and Foxp3 in CD4 T cells, IL-10 in B cells, and IDO in pDCs 
      were analyzed by flow cytometry in peripheral blood. The main cellular 
      participation in both lupus groups was IL-17- and IL-22-producing cell responses 
      both at skin and at peripheral blood but prevailed in DLE. The CLASI activity 
      scores negatively correlated with Th22 subpopulation and positively correlated 
      with CD25(+)/Foxp3(+) Treg cells. In conclusion a proinflammatory and regulatory 
      imbalance coexists in cutaneous lupus, both responses being more intense in DLE.
FAU - Mendez-Flores, Silvia
AU  - Mendez-Flores S
AD  - Department of Dermatology, Instituto Nacional de Ciencias Medicas y Nutricion, 
      Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, 14080 Mexico 
      City, DF, Mexico.
FAU - Hernandez-Molina, Gabriela
AU  - Hernandez-Molina G
AD  - Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas 
      y Nutricion, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, 
      14080 Mexico City, DF, Mexico.
FAU - Enriquez, Ana Bety
AU  - Enriquez AB
AD  - Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas 
      y Nutricion, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, 
      14080 Mexico City, DF, Mexico.
FAU - Faz-Munoz, David
AU  - Faz-Munoz D
AD  - Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas 
      y Nutricion, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, 
      14080 Mexico City, DF, Mexico.
FAU - Esquivel, Yeraldin
AU  - Esquivel Y
AD  - Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas 
      y Nutricion, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, 
      14080 Mexico City, DF, Mexico.
FAU - Pacheco-Molina, Carlos
AU  - Pacheco-Molina C
AD  - Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas 
      y Nutricion, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, 
      14080 Mexico City, DF, Mexico.
FAU - Furuzawa-Carballeda, Janette
AU  - Furuzawa-Carballeda J
AUID- ORCID: 0000-0001-5804-7221
AD  - Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas 
      y Nutricion, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, 
      14080 Mexico City, DF, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20160306
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukins)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Interferon-gamma/metabolism
MH  - Interleukin-10/metabolism
MH  - Interleukin-17/metabolism
MH  - Interleukin-4/metabolism
MH  - Interleukins/metabolism
MH  - Lupus Erythematosus, Cutaneous/*immunology/*metabolism
MH  - Middle Aged
MH  - T-Lymphocytes, Regulatory/*immunology/*metabolism
MH  - Young Adult
MH  - Interleukin-22
PMC - PMC4799821
EDAT- 2016/04/05 06:00
MHDA- 2016/12/31 06:00
PMCR- 2016/03/06
CRDT- 2016/04/05 06:00
PHST- 2015/12/05 00:00 [received]
PHST- 2016/02/01 00:00 [revised]
PHST- 2016/02/03 00:00 [accepted]
PHST- 2016/04/05 06:00 [entrez]
PHST- 2016/04/05 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
PHST- 2016/03/06 00:00 [pmc-release]
AID - 10.1155/2016/7074829 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2016;2016:7074829. doi: 10.1155/2016/7074829. Epub 2016 Mar 6.