PMID- 27042130
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160404
LR  - 20200930
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 9
DP  - 2016
TI  - Effects of long-term exercise training on adipose tissue expression of 
      fractalkine and MCP-1 in patients with type 2 diabetes and stable coronary artery 
      disease: a substudy of a randomized controlled trial.
PG  - 55-62
LID - 10.2147/DMSO.S96299 [doi]
AB  - PURPOSE: Adipose tissue inflammation plays a role in atherosclerosis and type 2 
      diabetes (T2DM). We aimed to investigate whether 12 months of exercise training 
      in patients with both T2DM and coronary artery disease (CAD) reduced the genetic 
      expression of the proinflammatory markers fractalkine (CX3CL1) and its receptor 
      (CX3CR1) and monocyte chemoattractant protein-1 (MCP-1) in the subcutaneous 
      adipose tissue. Expression of the genes in the circulating leukocytes and 
      circulating levels of the markers were also investigated. PATIENTS AND METHODS: A 
      total of 137 patients with T2DM and CAD were included to study the effects of 
      exercise on atherosclerosis progression and glucose control. Patients were 
      randomized to exercise training (combined aerobic and strength training) or 
      control. At inclusion and after 12 months, fasting blood samples and a 
      subcutaneous adipose tissue sample were taken. RNA was extracted from the adipose 
      tissue and circulating leukocytes, and the expression levels were examined by 
      reverse transcription-polymerase chain reaction. Circulating fractalkine and 
      MCP-1 were determined by enzyme-linked immunosorbent assay. RESULTS: The analyses 
      were performed in 114 patients who completed the study and adhered to the 
      intervention principle. At baseline, gene expression of fractalkine and CX3CR1 in 
      the adipose tissue was similar in the two groups. There were no change within 
      either group and no between-group differences in changes from baseline. 
      Circulating fractalkine increased after 12 months in the exercise group 
      (P=0.044), significantly more compared to controls (P=0.042), however only in the 
      patients with advanced vascular disease. Neither the expression levels of MCP-1 
      nor the circulating levels changed significantly in either group. At baseline, 
      CX3CR1 expression in the adipose tissue was associated with body mass index 
      (P<0.001). CONCLUSION: No significant effects of long-term exercise training on 
      adipose tissue expression of fractalkine, CX3CR1, or MCP-1 were found in our 
      patients with combined CAD and T2DM. However, a slight increase in circulating 
      fractalkine after the intervention was recorded. The association of CX3CR1 
      expression with body mass index might indicate increased immune activation in the 
      adipose tissue.
FAU - Njerve, Ida Unhammer
AU  - Njerve IU
AD  - Department of Cardiology, Center for Clinical Heart Research, Oslo University 
      Hospital, Ulleval, Oslo, Norway; Center for Heart Failure Research, Oslo 
      University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Byrkjeland, Rune
AU  - Byrkjeland R
AD  - Department of Cardiology, Center for Clinical Heart Research, Oslo University 
      Hospital, Ulleval, Oslo, Norway; Center for Heart Failure Research, Oslo 
      University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Arnesen, Harald
AU  - Arnesen H
AD  - Department of Cardiology, Center for Clinical Heart Research, Oslo University 
      Hospital, Ulleval, Oslo, Norway; Center for Heart Failure Research, Oslo 
      University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Akra, Sissel
AU  - Akra S
AD  - Department of Cardiology, Center for Clinical Heart Research, Oslo University 
      Hospital, Ulleval, Oslo, Norway; Center for Heart Failure Research, Oslo 
      University Hospital, Oslo, Norway.
FAU - Solheim, Svein
AU  - Solheim S
AD  - Department of Cardiology, Center for Clinical Heart Research, Oslo University 
      Hospital, Ulleval, Oslo, Norway; Center for Heart Failure Research, Oslo 
      University Hospital, Oslo, Norway.
FAU - Seljeflot, Ingebjorg
AU  - Seljeflot I
AD  - Department of Cardiology, Center for Clinical Heart Research, Oslo University 
      Hospital, Ulleval, Oslo, Norway; Center for Heart Failure Research, Oslo 
      University Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
LA  - eng
PT  - Journal Article
DEP - 20160314
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC4798200
OTO - NOTNLM
OT  - MCP-1
OT  - coronary artery disease
OT  - diabetes
OT  - exercise
OT  - fractalkine (CX3CL1)
OT  - subcutaneous adipose tissue
EDAT- 2016/04/05 06:00
MHDA- 2016/04/05 06:01
PMCR- 2016/03/14
CRDT- 2016/04/05 06:00
PHST- 2016/04/05 06:00 [entrez]
PHST- 2016/04/05 06:00 [pubmed]
PHST- 2016/04/05 06:01 [medline]
PHST- 2016/03/14 00:00 [pmc-release]
AID - dmso-9-055 [pii]
AID - 10.2147/DMSO.S96299 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2016 Mar 14;9:55-62. doi: 10.2147/DMSO.S96299. 
      eCollection 2016.