PMID- 27043640
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160405
LR  - 20200930
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 4
IP  - 2
DP  - 2016 Mar 28
TI  - Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for 
      Endocytic Receptors as a Promising Strategy for Future Therapies.
LID - 10.3390/vaccines4020008 [doi]
LID - 8
AB  - Dendritic cells (DCs) are the most potent professional antigen presenting cells 
      and are therefore indispensable for the control of immunity. The technique of 
      antibody mediated antigen targeting to DC subsets has been the basis of intense 
      research for more than a decade. Many murine studies have utilized this approach 
      of antigen delivery to various kinds of endocytic receptors of DCs both in vitro 
      and in vivo. Today, it is widely accepted that different DC subsets are important 
      for the induction of select immune responses. Nevertheless, many questions still 
      remain to be answered, such as the actual influence of the targeted receptor on 
      the initiation of the immune response to the delivered antigen. Further efforts 
      to better understand the induction of antigen-specific immune responses will 
      support the transfer of this knowledge into novel treatment strategies for human 
      diseases. In this review, we will discuss the state-of-the-art aspects of the 
      basic principles of antibody mediated antigen targeting approaches. A table will 
      also provide a broad overview of the latest studies using antigen targeting 
      including addressed DC subset, targeted receptors, outcome, and applied coupling 
      techniques.
FAU - Lehmann, Christian H K
AU  - Lehmann CH
AD  - Laboratory of DC-Biology, Department of Dermatology, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, University Hospital Erlangen, 
      Hartmannstr. 14, Erlangen 91052, Germany. christian.lehmann@uk-erlangen.de.
FAU - Heger, Lukas
AU  - Heger L
AD  - Laboratory of DC-Biology, Department of Dermatology, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, University Hospital Erlangen, 
      Hartmannstr. 14, Erlangen 91052, Germany. lukas.heger@uk-erlangen.de.
FAU - Heidkamp, Gordon F
AU  - Heidkamp GF
AD  - Laboratory of DC-Biology, Department of Dermatology, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, University Hospital Erlangen, 
      Hartmannstr. 14, Erlangen 91052, Germany. gordon.heidkamp@uk-erlangen.de.
FAU - Baranska, Anna
AU  - Baranska A
AD  - Laboratory of DC-Biology, Department of Dermatology, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, University Hospital Erlangen, 
      Hartmannstr. 14, Erlangen 91052, Germany. baranska@ciml.univ-mrs.fr.
AD  - Centre d'Immunologie de Marseille-Luminy, Aix Marseille Universite, INSERM-CNRS, 
      Marseille-Luminy 13288, France. baranska@ciml.univ-mrs.fr.
FAU - Luhr, Jennifer J
AU  - Luhr JJ
AD  - Laboratory of DC-Biology, Department of Dermatology, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, University Hospital Erlangen, 
      Hartmannstr. 14, Erlangen 91052, Germany. jennifer.luhr@uk-erlangen.de.
FAU - Hoffmann, Alana
AU  - Hoffmann A
AD  - Laboratory of DC-Biology, Department of Dermatology, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, University Hospital Erlangen, 
      Hartmannstr. 14, Erlangen 91052, Germany. alana.hoffmann@uk-erlangen.de.
FAU - Dudziak, Diana
AU  - Dudziak D
AD  - Laboratory of DC-Biology, Department of Dermatology, 
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, University Hospital Erlangen, 
      Hartmannstr. 14, Erlangen 91052, Germany. diana.dudziak@uk-erlangen.de.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160328
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC4931625
OTO - NOTNLM
OT  - CLR
OT  - DC
OT  - DCIR
OT  - DEC205
OT  - antigen targeting
OT  - antigen targeting antibodies
OT  - cancer
OT  - dendritic cell subsets
OT  - moDC
OT  - vaccine
EDAT- 2016/04/05 06:00
MHDA- 2016/04/05 06:01
PMCR- 2016/03/28
CRDT- 2016/04/05 06:00
PHST- 2016/02/19 00:00 [received]
PHST- 2016/03/15 00:00 [revised]
PHST- 2016/03/18 00:00 [accepted]
PHST- 2016/04/05 06:00 [entrez]
PHST- 2016/04/05 06:00 [pubmed]
PHST- 2016/04/05 06:01 [medline]
PHST- 2016/03/28 00:00 [pmc-release]
AID - vaccines4020008 [pii]
AID - vaccines-04-00008 [pii]
AID - 10.3390/vaccines4020008 [doi]
PST - epublish
SO  - Vaccines (Basel). 2016 Mar 28;4(2):8. doi: 10.3390/vaccines4020008.