PMID- 27045551
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20181113
IS  - 1488-2434 (Electronic)
IS  - 1180-4882 (Print)
IS  - 1180-4882 (Linking)
VI  - 41
IP  - 6
DP  - 2016 Oct
TI  - Partially restored resting-state functional connectivity in women recovered from 
      anorexia nervosa.
PG  - 377-385
AB  - BACKGROUND: We have previously shown increased resting-state functional 
      connectivity (rsFC) in the frontoparietal network (FPN) and the default mode 
      network (DMN) in patients with acute anorexia nervosa. Based on these findings we 
      investigated within-network rsFC in patients recovered from anorexia nervosa to 
      examine whether these abnormalities are a state or trait marker of the disease. 
      To extend the understanding of functional connectivity in patients with anorexia 
      nervosa, we also estimated rsFC between large-scale networks. METHODS: Girls and 
      women recovered from anorexia nervosa and pair-wise, age- and sex-matched healthy 
      controls underwent a resting-state fMRI scan. Using independent component 
      analyses (ICA), we isolated the FPN, DMN and salience network. We used standard 
      comparisons as well as a hypothesis-based approach to test the findings of our 
      previous rsFC study in this recovered cohort. Temporal correlations between 
      network time-course pairs were computed to investigate functional network 
      connectivity (FNC). RESULTS: Thirty-one patients recovered from anorexia nervosa 
      and 31 controls participated in our study. Standard group comparisons revealed 
      reduced rsFC between the dorsolateral prefrontal cortex (dlPFC) and the FPN in 
      the recovered group. Using a hypothesis-based approach we extended the previous 
      finding of increased rsFC between the angular gyrus and the FPN in patients 
      recovered from anorexia nervosa. No group differences in FNC were revealed. 
      LIMITATIONS: The study design did not allow us to conclude that the difference 
      found in rsFC constitutes a scar effect of the disease. CONCLUSION: This study 
      suggests that some abnormal rsFC patterns found in patients recovered from 
      anorexia nervosa normalize after long-term weight restoration, while distorted 
      rsFC in the FPN, a network that has been associated with cognitive control, may 
      constitute a trait marker of the disorder.
FAU - Boehm, Ilka
AU  - Boehm I
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Geisler, Daniel
AU  - Geisler D
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Tam, Friederike
AU  - Tam F
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - King, Joseph A
AU  - King JA
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Ritschel, Franziska
AU  - Ritschel F
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Seidel, Maria
AU  - Seidel M
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Bernardoni, Fabio
AU  - Bernardoni F
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Murr, Julia
AU  - Murr J
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Goschke, Thomas
AU  - Goschke T
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Calhoun, Vince D
AU  - Calhoun VD
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Roessner, Veit
AU  - Roessner V
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
FAU - Ehrlich, Stefan
AU  - Ehrlich S
AD  - From the Eating Disorder Services and Research Center, Department of Child and 
      Adolescent Psychiatry, Faculty of Medicine, Technische Universitat Dresden, 
      Dresden, Germany (Boehm, Geisler, Tam, King, Ritschel, Seidel, Bernardoni, 
      Roessner, Ehrlich); the MGH/MIT/HMS Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, Charlestown, MA (Ehrlich); the Harvard Medical 
      School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 
      (Ehrlich); the Department of Psychotherapy and Psychosomatic Medicine, Faculty of 
      Medicine, Technische Universitat Dresden, Dresden, Germany (Murr); the Department 
      of Psychology, Technische Universitat Dresden, Dresden, Germany (Goschke); the 
      The Mind Research Network, Albuquerque, New Mexico (Calhoun); and the Department 
      of ECE, the University of New Mexico, Albuquerque, New Mexico (Calhoun).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Psychiatry Neurosci
JT  - Journal of psychiatry & neuroscience : JPN
JID - 9107859
SB  - IM
MH  - Anorexia Nervosa/diagnostic imaging/*physiopathology
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Brain Mapping
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Rest
MH  - Young Adult
PMC - PMC5082508
EDAT- 2016/10/22 06:00
MHDA- 2018/01/05 06:00
PMCR- 2016/11/01
CRDT- 2016/04/06 06:00
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
PHST- 2016/04/06 06:00 [entrez]
PHST- 2016/11/01 00:00 [pmc-release]
AID - 10.1503/jpn.150259 [pii]
AID - jpn-41-377 [pii]
AID - 10.1503/jpn.150259 [doi]
PST - ppublish
SO  - J Psychiatry Neurosci. 2016 Oct;41(6):377-385. doi: 10.1503/jpn.150259.