PMID- 27046394 OWN - NLM STAT- MEDLINE DCOM- 20170209 LR - 20220321 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 239 DP - 2016 May 30 TI - Psychosocial functioning, quality of life and clinical correlates of comorbid alcohol and drug dependence syndromes in people with schizophrenia across Europe. PG - 301-7 LID - S0165-1781(16)30504-2 [pii] LID - 10.1016/j.psychres.2016.03.038 [doi] AB - Little is known about the correlates of comorbid drug and alcohol dependence in people with schizophrenia outside the USA. We tested hypotheses that dependence on alcohol/drugs would be associated with more severe symptoms, and poorer psychosocial functioning and quality of life. The EuroSC Cohort study (N=1204), based in France, Germany and the UK, used semi-structured clinical interviews for diagnoses, and standardized tools to assess correlates. We used mixed models to compare outcomes between past-year comorbid dependence on alcohol/drugs, controlling for covariates and modelling both subject and country-level effects. Participants dependent on alcohol or drugs had fewer negative symptoms on PANSS than their non-dependent counterparts. However, those dependent on alcohol scored higher on PANSS general psychopathology than those who were not, or dependent only on drugs. People with schizophrenia dependent on drugs had poorer quality of life, more extrapyramidal side effects, and scored worse on Global Assessment of Functioning (GAF) than those without dependence. People with alcohol dependence reported more reasons for non-compliance with medication, and poorer functioning on GAF, though not on Global Assessment of Relational Functioning. In people with schizophrenia, comorbid dependence on alcohol or drugs is associated with impaired clinical and psychosocial adjustment, and poorer quality of life. CI - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved. FAU - Carra, Giuseppe AU - Carra G AD - Division of Psychiatry (Formerly Mental Health Sciences), University College London, 6th Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK. Electronic address: g.carra@ucl.ac.uk. FAU - Johnson, Sonia AU - Johnson S AD - Division of Psychiatry (Formerly Mental Health Sciences), University College London, 6th Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK. Electronic address: s.johnson@ucl.ac.uk. FAU - Crocamo, Cristina AU - Crocamo C AD - Department of Public Health, Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Via Forlanini 2, 27100 Pavia, Italy. Electronic address: cristina.crocamo01@universitadipavia.it. FAU - Angermeyer, Matthias C AU - Angermeyer MC AD - Department of Psychiatry, University of Leipzig, Johannisallee 20, 04137 Leipzig, Germany. Electronic address: angermeyer@aon.at. FAU - Brugha, Traolach AU - Brugha T AD - Department of Health Sciences, University of Leicester, 22-28 Princess Road West, Leicester LE1 6TP, UK. Electronic address: tsb@le.ac.uk. FAU - Azorin, Jean-Michel AU - Azorin JM AD - SHU Psychiatrie Adultes, Hopital Sainte Marguerite, 13274 Marseille Cedex 9, France. Electronic address: Jean-michelRoch.AZORIN@ap-hm.fr. FAU - Toumi, Mondher AU - Toumi M AD - Chair of Market Access, University Claude Bernard Lyon I, UFR d'Odontologie 11, Rue Guillaume Paradin, 69008 Lyon, France. Electronic address: mondher.toumi@univ-lyon1.fr. FAU - Bebbington, Paul E AU - Bebbington PE AD - Division of Psychiatry (Formerly Mental Health Sciences), University College London, 6th Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK. Electronic address: p.bebbington@ucl.ac.uk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160326 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Adult MH - Cohort Studies MH - Europe MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Quality of Life MH - Schizophrenia/*complications MH - *Schizophrenic Psychology MH - *Social Adjustment MH - Substance-Related Disorders/complications/*psychology MH - Young Adult OTO - NOTNLM OT - Alcohol dependence OT - Comorbidity OT - Drug dependence OT - Schizophrenia EDAT- 2016/04/06 06:00 MHDA- 2017/02/10 06:00 CRDT- 2016/04/06 06:00 PHST- 2015/07/07 00:00 [received] PHST- 2016/01/27 00:00 [revised] PHST- 2016/03/23 00:00 [accepted] PHST- 2016/04/06 06:00 [entrez] PHST- 2016/04/06 06:00 [pubmed] PHST- 2017/02/10 06:00 [medline] AID - S0165-1781(16)30504-2 [pii] AID - 10.1016/j.psychres.2016.03.038 [doi] PST - ppublish SO - Psychiatry Res. 2016 May 30;239:301-7. doi: 10.1016/j.psychres.2016.03.038. Epub 2016 Mar 26.