PMID- 27047375
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160406
LR  - 20200930
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 8
DP  - 2016
TI  - Frequency-Dependent Brain Regional Homogeneity Alterations in Patients with Mild 
      Cognitive Impairment during Working Memory State Relative to Resting State.
PG  - 60
LID - 10.3389/fnagi.2016.00060 [doi]
LID - 60
AB  - Several studies have reported working memory deficits in patients with mild 
      cognitive impairment (MCI). However, previous studies investigating the neural 
      mechanisms of MCI have primarily focused on brain activity alterations during 
      working memory tasks. No study to date has compared brain network alterations in 
      the working memory state between MCI patients and normal control (NC) subjects. 
      Therefore, using the index of regional homogeneity (ReHo), we explored brain 
      network impairments in MCI patients during a working memory task relative to the 
      resting state, and identified frequency-dependent effects in separate frequency 
      bands.Our results indicate that, in MCI patients, ReHo is altered in the 
      posterior cingulate cortex (PCC) in the slow-3 band (0.073-0.198 Hz), and in the 
      bottom of the right occipital lobe and part of the right cerebellum, the right 
      thalamus, a diffusing region in the bilateral prefrontal cortex (PFC), the left 
      and right parietal-occipital regions, and the right angular gyrus in the slow-5 
      band (0.01-0.027 Hz). Furthermore, in NCs, the value of ReHo in clusters 
      belonging to the default mode network (DMN) decreased, while the value of ReHo in 
      clusters belonging to the attentional network increased during the task state. 
      However, this pattern was reversed in MCI patients, and was associated with 
      decreased working memory performance. In addition, we identified altered 
      functional connectivity of the abovementioned regions with other parts of the 
      brain in MCI patients. This is the first study to compare frequency-dependent 
      alterations of ReHo in MCI patients between resting and working memory states. 
      The results provide a new perspective regarding the neural mechanisms of working 
      memory deficits in MCI patients, and extend our knowledge of altered brain 
      patterns in resting and task-evoked states.
FAU - Wang, Pengyun
AU  - Wang P
AD  - Key Laboratory of Mental Health, Center on Aging Psychology, Institute of 
      Psychology, Chinese Academy of Sciences Beijing, China.
FAU - Li, Rui
AU  - Li R
AD  - Key Laboratory of Mental Health, Center on Aging Psychology, Institute of 
      Psychology, Chinese Academy of Sciences Beijing, China.
FAU - Yu, Jing
AU  - Yu J
AD  - Faculty of Psychology, Southwest University Chongqing, China.
FAU - Huang, Zirui
AU  - Huang Z
AD  - Institute of Mental Health Research, University of Ottawa Ottawa, ON, Canada.
FAU - Li, Juan
AU  - Li J
AD  - Key Laboratory of Mental Health, Center on Aging Psychology, Institute of 
      Psychology, Chinese Academy of Sciences Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20160324
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4805610
OTO - NOTNLM
OT  - frequency bands
OT  - mild cognitive impairment
OT  - regional homogeneity
OT  - state
OT  - working memory
EDAT- 2016/04/06 06:00
MHDA- 2016/04/06 06:01
PMCR- 2016/01/01
CRDT- 2016/04/06 06:00
PHST- 2015/12/29 00:00 [received]
PHST- 2016/03/10 00:00 [accepted]
PHST- 2016/04/06 06:00 [entrez]
PHST- 2016/04/06 06:00 [pubmed]
PHST- 2016/04/06 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2016.00060 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2016 Mar 24;8:60. doi: 10.3389/fnagi.2016.00060. 
      eCollection 2016.