PMID- 27047645
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160406
LR  - 20200930
IS  - 2008-3009 (Print)
IS  - 2008-2207 (Electronic)
IS  - 2008-2207 (Linking)
VI  - 10
IP  - 1
DP  - 2016 Jan 1
TI  - Hematological and biochemical status of Beta-thalassemia major patients in 
      Bangladesh: A comparative analysis.
PG  - 7-12
AB  - BACKGROUND: Thalassemia is one of the most common hereditary disorders and 
      Beta-thalassemia major is its severe form. The present study is concerned with 
      the analysis of liver function, thyroid function and estimation of critical serum 
      ions as well as hematological characteristics in beta-thalassemia patients and 
      controls. SUBJECTS AND METHODS: The study included 54 patients with 
      beta-thalassemia major and 54 healthy individuals matched by sex and age. The 
      activity of Alanine transaminase (ALT), Alkaline phosphatase (ALP) and Aspartate 
      transaminase (AST) were assessed in order to evaluate the liver function. Serum 
      content of iron (Fe), calcium (Ca), magnesium (Mg), sodium (Na) and potassium (K) 
      were also estimated. Tri iodothyronine (T3), Thyroxin (T4) and 
      Thyroid-stimulating hormone (TSH) levels were assessed in order to evaluate the 
      thyroid function. Hemoglobin (Hb), ferritin, hematocrit (HCT), mean corpuscular 
      volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin 
      concentration(MCHC), total iron binding capacity (TIBC) and creatinine level were 
      also measured. RESULTS: Significantly, higher ALT (P< 0.001), AST (P< 0.05), ALP 
      (P< 0.001) activities and lower creatinine (P< 0.001) level in beta-thalassemia 
      patients were found in comparison to healthy individuals. Lower serum level of 
      calcium (P< 0.05), magnesium (P< 0.05) and higher level of iron (P> 0.05), sodium 
      (P> 0.05) and potassium (P > 0.05) have been found in patients in comparison to 
      healthy individuals. Hematological parameters like Hb (P< 0.001), ferritin (P< 
      0.05), HCT (P< 0.001), MCV (P< 0.05) and MCH (P< 0.05) have been significantly 
      reduced in patients except MCHC (P> 0.05). No significant difference was observed 
      in thyroid function between patients and control group. CONCLUSIONS: Our study 
      demonstrates that beta-thalassemia patients and controls have difference in liver 
      function, thyroid function, serum contents of ions and hematological 
      characteristics.
FAU - Karim, Md Fazlul
AU  - Karim MF
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, 
      Dhaka-1000, Bangladesh.
FAU - Ismail, Md
AU  - Ismail M
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, 
      Dhaka-1000, Bangladesh.
FAU - Hasan, Akm Mahbub
AU  - Hasan AM
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, 
      Dhaka-1000, Bangladesh.
FAU - Shekhar, Hossain Uddin
AU  - Shekhar HU
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, 
      Dhaka-1000, Bangladesh.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Hematol Oncol Stem Cell Res
JT  - International journal of hematology-oncology and stem cell research
JID - 101511150
PMC - PMC4818791
OTO - NOTNLM
OT  - Beta-thalassemia major
OT  - Hematological characteristics
OT  - Liver function
OT  - Thyroid function
EDAT- 2016/04/06 06:00
MHDA- 2016/04/06 06:01
PMCR- 2016/01/01
CRDT- 2016/04/06 06:00
PHST- 2016/04/06 06:00 [entrez]
PHST- 2016/04/06 06:00 [pubmed]
PHST- 2016/04/06 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - IJHOSCR-10-7 [pii]
PST - ppublish
SO  - Int J Hematol Oncol Stem Cell Res. 2016 Jan 1;10(1):7-12.