PMID- 27048764 OWN - NLM STAT- MEDLINE DCOM- 20160801 LR - 20220321 IS - 1941-3297 (Electronic) IS - 1941-3289 (Print) IS - 1941-3289 (Linking) VI - 9 IP - 4 DP - 2016 Apr TI - Burden of Systolic and Diastolic Left Ventricular Dysfunction Among Hispanics in the United States: Insights From the Echocardiographic Study of Latinos. PG - e002733 LID - 10.1161/CIRCHEARTFAILURE.115.002733 [doi] LID - 10.1161/CIRCHEARTFAILURE.115.002733 e002733 AB - BACKGROUND: Population-based estimates of cardiac dysfunction and clinical heart failure (HF) remain undefined among Hispanics/Latino adults. METHODS AND RESULTS: Participants of Hispanic/Latino origin across the United States aged 45 to 74 years were enrolled into the Echocardiographic Study of Latinos (ECHO-SOL) and underwent a comprehensive echocardiography examination to define left ventricular systolic dysfunction (LVSD) and left ventricular diastolic dysfunction (LVDD). Clinical HF was defined according to self-report, and those with cardiac dysfunction but without clinical HF were characterized as having subclinical or unrecognized cardiac dysfunction. Of 1818 ECHO-SOL participants (mean age 56.4 years; 42.6% male), 49.7% had LVSD or LVDD or both. LVSD prevalence was 3.6%, whereas LVDD was detected in 50.3%. Participants with LVSD were more likely to be males and current smokers (all P<0.05). Female sex, hypertension, diabetes mellitus, higher body mass index, and renal dysfunction were more common among those with LVDD (all P<0.05). In age-sex adjusted models, individuals of Central American and Cuban backgrounds were almost 2-fold more likely to have LVDD compared with those of Mexican backgrounds. Prevalence of clinical HF with LVSD (HF with reduced EF) was 7.3%; prevalence of clinical HF with LVDD (HF with preserved EF) was 3.6%. 96.1% of the cardiac dysfunction seen was subclinical or unrecognized. Compared with those with clinical cardiac dysfunction, prevalent coronary heart disease was the only factor independently associated with subclinical or unrecognized cardiac dysfunction (odds ratio: 0.1; 95% confidence interval: 0.1-0.4). CONCLUSIONS: Among Hispanics/Latinos, most cardiac dysfunction is subclinical or unrecognized, with a high prevalence of diastolic dysfunction. This identifies a high-risk population for the development of clinical HF. CI - (c) 2016 American Heart Association, Inc. FAU - Mehta, Hardik AU - Mehta H AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Armstrong, Anderson AU - Armstrong A AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Swett, Katrina AU - Swett K AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Shah, Sanjiv J AU - Shah SJ AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Allison, Matthew A AU - Allison MA AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Hurwitz, Barry AU - Hurwitz B AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Bangdiwala, Shrikant AU - Bangdiwala S AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Dadhania, Rupal AU - Dadhania R AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Kitzman, Dalane W AU - Kitzman DW AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Arguelles, William AU - Arguelles W AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Lima, Joao AU - Lima J AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Youngblood, Marston AU - Youngblood M AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Schneiderman, Neil AU - Schneiderman N AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Daviglus, Martha L AU - Daviglus ML AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Spevack, Daniel AU - Spevack D AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Talavera, Greg A AU - Talavera GA AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Raisinghani, Ajit AU - Raisinghani A AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Kaplan, Robert AU - Kaplan R AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). FAU - Rodriguez, Carlos J AU - Rodriguez CJ AD - From the Department of Medicine, Section on Cardiovascular Medicine and Department of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC (H.M., K.S., R.D., D.W.K., C.J.R.); Department of Cardiology, Johns Hopkins University, Baltimore, MD (A.A., J.L.); Department of Medicine and Cardiology, Northwestern University, Chicago, IL (S.J.S.); Department of Family Medicine and Public Health, Division of Preventive Medicine (M.A.A.), and Division of Cardiovascular Medicine (A.R.), University of California at San Diego; Department of Psychology, University of Miami (B.H., W.A., N.S.); Departments of Biostatistics, University of North Carolina, Chapel Hill (S.B., M.Y.); Department of Medicine, University of Illinois at Chicago (M.L.D.); Department of Epidemiology and Population Health, Albert Einstein School of Medicine, Bronx, NY (D.S., R.K.); and Department of Public Health, San Diego State University, CA (G.A.T.). crodrigu@wakehealth.edu. LA - eng GR - R01 HL104199/HL/NHLBI NIH HHS/United States GR - N01HC65236/HL/NHLBI NIH HHS/United States GR - N01HC65235/HL/NHLBI NIH HHS/United States GR - N01-HC65237/HC/NHLBI NIH HHS/United States GR - N01HC65234/HL/NHLBI NIH HHS/United States GR - N01HC65233/HL/NHLBI NIH HHS/United States GR - N01HC65237/HL/NHLBI NIH HHS/United States GR - N01-HC65233/HC/NHLBI NIH HHS/United States GR - P30 DK020541/DK/NIDDK NIH HHS/United States GR - N01-HC65234/HC/NHLBI NIH HHS/United States GR - N01-HC65236/HC/NHLBI NIH HHS/United States GR - N01-HC65235/HC/NHLBI NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PL - United States TA - Circ Heart Fail JT - Circulation. Heart failure JID - 101479941 SB - IM MH - Aged MH - Chi-Square Distribution MH - *Diastole MH - *Echocardiography, Doppler MH - Female MH - Heart Failure/*diagnostic imaging/*ethnology/physiopathology MH - *Hispanic or Latino MH - Humans MH - Logistic Models MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Odds Ratio MH - Predictive Value of Tests MH - Prevalence MH - Risk Factors MH - *Systole MH - United States/epidemiology MH - Ventricular Dysfunction, Left/*diagnostic imaging/*ethnology/physiopathology MH - *Ventricular Function, Left PMC - PMC4826756 MID - NIHMS761294 OTO - NOTNLM OT - Hispanics OT - diastolic dysfunction echocardiography OT - echocardiography OT - heart failure OT - systolic dysfunction EDAT- 2016/04/07 06:00 MHDA- 2016/08/02 06:00 PMCR- 2017/04/01 CRDT- 2016/04/07 06:00 PHST- 2015/07/13 00:00 [received] PHST- 2016/02/10 00:00 [accepted] PHST- 2016/04/07 06:00 [entrez] PHST- 2016/04/07 06:00 [pubmed] PHST- 2016/08/02 06:00 [medline] PHST- 2017/04/01 00:00 [pmc-release] AID - CIRCHEARTFAILURE.115.002733 [pii] AID - 10.1161/CIRCHEARTFAILURE.115.002733 [doi] PST - ppublish SO - Circ Heart Fail. 2016 Apr;9(4):e002733. doi: 10.1161/CIRCHEARTFAILURE.115.002733.