PMID- 27049262
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 20
IP  - 6
DP  - 2016
TI  - Mechanism of action of EBV, Bcl-2, p53, c-Myc and Rb in non-Hodgkin's lymphoma.
PG  - 1093-7
LID - 10502 [pii]
AB  - OBJECTIVE: The aim of the present study is to explore the mechanism of action of 
      several proteins, including Epstein-Barr virus (EBV), B-cell lymphoma (Bcl)-2, 
      p53, c-Myc and retinoblastoma (Rb), in Non-Hodgkin's lymphoma (NHL). PATIENTS AND 
      METHODS: Between July 2010 and July 2015, samples of 142 patients with 
      pathologically confirmed NHL which presented at our institution were included in 
      the observation group. In addition, samples from 55 patients with hyperplastic 
      lymphadenitis presented during the same period were enrolled as control group. 
      The expressions of EBV (+), p53(+), Bcl-2(+), Rb(-) and c-Myc(+) were determined 
      and compared PATIENTS AND METHODS: Between July 2010 and July 2015, samples of 
      142 patients with pathologically confirmed NHL which presented at our institution 
      were included in the observation group. In addition, samples from 55 patients 
      with hyperplastic lymphadenitis presented during the same period were enrolled as 
      control group. The expressions of EBV (+), p53(+), Bcl-2(+), Rb(-) and c-Myc(+) 
      were determined and compared among different subtypes and stages of NHLs of 
      observation group. Besides, the correlation of EBV with p53, Bcl-2, Rb and c-Myc 
      were investigated in NHLs of observation group. RESULTS: In the observation 
      group, the expression rates of EBV(+), p53(+), Bcl-2(+), Rb(-), and c-Myc(+) were 
      significantly higher than those, respectively, in the control group (p < 0.05). 
      No significant correlation was observed between EBV expression and the 
      expressions of p53, Bcl-2, Rb and c-Myc in the observation group (p > 0.05). The 
      expression rates of p53(+) and Bcl-2(+) were significantly higher in aggressive 
      and highly-aggressive NHLs than in indolent NHLs of the observation group (p < 
      0.05). The expressions of EBV(+), p53(+), Bcl-2(+), Rb(-), and c-Myc(+) were 
      significantly higher in stage III-IV NHLs than in stage I-II NHLs (p < 0.05). 
      CONCLUSIONS: The expressions of EBV(+), p53(+), Bcl-2(+), Rb(-), and c-Myc(+) are 
      closely associated with NHL pathogenesis. Expressions of these proteins are 
      higher in later stages of NHLs, and expressions of p53(+) and Bcl-2(+) are higher 
      in more aggressive NHLs.
FAU - Song, W
AU  - Song W
AD  - Department of Pathology, Zhengzhou University Affiliated Cancer Hospital (Henan 
      Cancer Hospital), Zhengzhou, China. qingkaiy@163.com.
FAU - Liu, M-G
AU  - Liu MG
FAU - Zhang, J-B
AU  - Zhang JB
FAU - Zhang, J-J
AU  - Zhang JJ
FAU - Sun, M-M
AU  - Sun MM
FAU - Yu, Q-K
AU  - Yu QK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, p53/*physiology
MH  - Herpesvirus 4, Human/genetics/*metabolism
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/diagnosis/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-bcl-2/*biosynthesis/genetics
MH  - Proto-Oncogene Proteins c-myc/*biosynthesis/genetics
MH  - Retinoblastoma Protein/*biosynthesis/genetics
EDAT- 2016/04/07 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/04/07 06:00
PHST- 2016/04/07 06:00 [entrez]
PHST- 2016/04/07 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10502 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2016;20(6):1093-7.