PMID- 27049439
OWN - NLM
STAT- MEDLINE
DCOM- 20170310
LR  - 20190424
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Apr 6
TI  - Spinal cord lesions shrink peripersonal space around the feet, passive 
      mobilization of paraplegic limbs restores it.
PG  - 24126
LID - 10.1038/srep24126 [doi]
LID - 24126
AB  - Peripersonal space (PPS) is the space surrounding us within which we interact 
      with objects. PPS may be modulated by actions (e.g. when using tools) or sense of 
      ownership (e.g. over a rubber hand). Indeed, intense and/or prolonged use of a 
      tool may induce a sense of ownership over it. Conversely, inducing ownership over 
      a rubber hand may activate brain regions involved in motor control. However, the 
      extent to which PPS is modulated by action-dependent or ownership-dependent 
      mechanisms remains unclear. Here, we explored the PPS around the feet and the 
      sense of ownership over lower limbs in people with Paraplegia following Complete 
      spinal cord Lesions (PCL) and in healthy subjects. PCL people can move their 
      upper body but have lost all sensory-motor functions in their lower body (e.g. 
      lower limbs). We tested whether PPS alterations reflect the topographical 
      representations of various body parts. We found that the PPS around the feet was 
      impaired in PCL who however had a normal representation of the PPS around the 
      hands. Significantly, passive mobilization of paraplegic limbs restored the PPS 
      around the feet suggesting that activating action representations in PCL brings 
      about short-term changes of PPS that may thus be more plastic than previously 
      believed.
FAU - Scandola, Michele
AU  - Scandola M
AD  - NPSY-Lab.VR, Department of Human Sciences, University of Verona, Verona I-37129, 
      Italy.
AD  - IRCCS, Fondazione Santa Lucia, Rome I-00179, Italy.
FAU - Aglioti, Salvatore Maria
AU  - Aglioti SM
AD  - Department of Psychology, University of Rome "Sapienza", Rome I-00185, Italy.
AD  - IRCCS, Fondazione Santa Lucia, Rome I-00179, Italy.
FAU - Bonente, Claudio
AU  - Bonente C
AD  - NPSY-Lab.VR, Department of Human Sciences, University of Verona, Verona I-37129, 
      Italy.
FAU - Avesani, Renato
AU  - Avesani R
AD  - Department of Rehabilitation, Sacro Cuore - Don Calabria Hospital, Negrar 
      I-37024, Verona, Italy.
FAU - Moro, Valentina
AU  - Moro V
AD  - NPSY-Lab.VR, Department of Human Sciences, University of Verona, Verona I-37129, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160406
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Bayes Theorem
MH  - Extremities/physiopathology
MH  - Female
MH  - Foot/*physiopathology
MH  - Humans
MH  - Male
MH  - Markov Chains
MH  - Middle Aged
MH  - Monte Carlo Method
MH  - Motion Therapy, Continuous Passive/*methods
MH  - Paraplegia/physiopathology/*therapy
MH  - *Personal Space
MH  - Psychomotor Performance/physiology
MH  - Space Perception/*physiology
MH  - Spinal Cord/*physiopathology
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC4822176
COIS- The authors declare no competing financial interests.
EDAT- 2016/04/07 06:00
MHDA- 2017/03/11 06:00
PMCR- 2016/04/06
CRDT- 2016/04/07 06:00
PHST- 2016/01/05 00:00 [received]
PHST- 2016/03/18 00:00 [accepted]
PHST- 2016/04/07 06:00 [entrez]
PHST- 2016/04/07 06:00 [pubmed]
PHST- 2017/03/11 06:00 [medline]
PHST- 2016/04/06 00:00 [pmc-release]
AID - srep24126 [pii]
AID - 10.1038/srep24126 [doi]
PST - epublish
SO  - Sci Rep. 2016 Apr 6;6:24126. doi: 10.1038/srep24126.