PMID- 27049554
OWN - NLM
STAT- MEDLINE
DCOM- 20160817
LR  - 20220311
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 293
DP  - 2016 Apr 15
TI  - Evidence of substance P autocrine circuitry that involves TNF-alpha, IL-6, and PGE2 
      in endogenous pyrogen-induced fever.
PG  - 1-7
LID - S0165-5728(16)30016-9 [pii]
LID - 10.1016/j.jneuroim.2016.01.016 [doi]
AB  - Substance P (SP) is involved in fever that is induced by lipopolysaccharide (LPS) 
      but not by interleukin-1beta or macrophage inflammatory protein-1alpha. 
      Intracerebroventricular (i.c.v.) administration of the neurokinin-1 (NK1) 
      receptor antagonist SR140333B in rats reduced fever that was induced by an i.c.v. 
      injection of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), prostaglandin 
      E2 (PGE2), corticotropin-releasing factor (CRF), endothelin-1 (ET-1), and 
      morphine (MOR). Furthermore, an i.c.v. injection of SP induced a febrile response 
      that was inhibited by indomethacin concomitant with an increase in PGE2 levels in 
      cerebrospinal fluid. Lipopolysaccharide and PGE2 caused higher expression and 
      internalization of NK1 receptors in the hypothalamus which were prevented by 
      SR140333B. These data suggest that SP is an important mediator of fever, in which 
      it induces a prostaglandin-dependent response and is released after TNF-alpha, IL-6, 
      PGE2, CRF, endogenous opioids, and ET-1.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Brito, Haissa Oliveira
AU  - Brito HO
AD  - Department of Pharmacology, Federal University of Parana, P.O. Box 19031, 
      Curitiba, PR 81540-970, Brazil.
FAU - Barbosa, Felipe L
AU  - Barbosa FL
AD  - Department of Pharmacology, Federal University of Parana, P.O. Box 19031, 
      Curitiba, PR 81540-970, Brazil.
FAU - Reis, Renata Cristiane Dos
AU  - Reis RCD
AD  - Department of Pharmacology, Federal University of Parana, P.O. Box 19031, 
      Curitiba, PR 81540-970, Brazil.
FAU - Fraga, Daniel
AU  - Fraga D
AD  - Department of Pharmacology, Federal University of Parana, P.O. Box 19031, 
      Curitiba, PR 81540-970, Brazil.
FAU - Borges, Beatriz S
AU  - Borges BS
AD  - Department of Cell Biology, Federal University of Parana, P.O. Box 19031, 
      Curitiba, PR 81540-970, Brazil.
FAU - Franco, Celia R C
AU  - Franco CRC
AD  - Department of Cell Biology, Federal University of Parana, P.O. Box 19031, 
      Curitiba, PR 81540-970, Brazil.
FAU - Zampronio, Aleksander Roberto
AU  - Zampronio AR
AD  - Department of Pharmacology, Federal University of Parana, P.O. Box 19031, 
      Curitiba, PR 81540-970, Brazil. Electronic address: aleksander@ufpr.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160127
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Interleukin-6)
RN  - 0 (Polysaccharides)
RN  - 0 (Pyrogens)
RN  - 0 (Receptors, Neurokinin-1)
RN  - 0 (SR140333B)
RN  - 0 (Tropanes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 33507-63-0 (Substance P)
RN  - 76I7G6D29C (Morphine)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
MH  - Body Temperature/drug effects
MH  - Corticotropin-Releasing Hormone/pharmacology
MH  - Dinoprostone/*cerebrospinal fluid
MH  - Fever/*chemically induced/*prevention & control
MH  - Gene Expression Regulation/drug effects
MH  - Hypothalamus/drug effects/metabolism
MH  - Indomethacin/pharmacology
MH  - Interleukin-6/administration & dosage/metabolism
MH  - Male
MH  - Morphine/pharmacology
MH  - Polysaccharides/toxicity
MH  - *Pyrogens
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Neurokinin-1/metabolism
MH  - Substance P/metabolism/*pharmacology
MH  - Time Factors
MH  - Tropanes/pharmacology
MH  - Tumor Necrosis Factor-alpha/metabolism/pharmacology
OTO - NOTNLM
OT  - Corticotroin-releasing factor
OT  - Cytokines
OT  - Endogenous opioids
OT  - Endothelin-1
OT  - Prostaglandin
OT  - Substance P
EDAT- 2016/04/07 06:00
MHDA- 2016/08/18 06:00
CRDT- 2016/04/07 06:00
PHST- 2015/10/29 00:00 [received]
PHST- 2016/01/11 00:00 [revised]
PHST- 2016/01/25 00:00 [accepted]
PHST- 2016/04/07 06:00 [entrez]
PHST- 2016/04/07 06:00 [pubmed]
PHST- 2016/08/18 06:00 [medline]
AID - S0165-5728(16)30016-9 [pii]
AID - 10.1016/j.jneuroim.2016.01.016 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2016 Apr 15;293:1-7. doi: 10.1016/j.jneuroim.2016.01.016. Epub 
      2016 Jan 27.