PMID- 27050802
OWN - NLM
STAT- MEDLINE
DCOM- 20160805
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 34
IP  - 3
DP  - 2016 May-Jun
TI  - Cardiac magnetic resonance imaging reveals frequent myocardial involvement and 
      dysfunction in active rheumatoid arthritis.
PG  - 416-23
AB  - OBJECTIVES: In rheumatoid arthritis (RA), cardiac involvement is common and often 
      subclinical. We used cardiovascular magnetic resonance (CMR) to identify 
      myocardial abnormalities in patients with active RA, free of clinical cardiac 
      disease. METHODS: Sixty female patients with active RA aged <70 years and 21 sex- 
      and age-matched control subjects underwent either 1.5T or 3T CMR imaging for 
      analyses of T1 relaxation times, late gadolinium enhancement (LGE), and the 
      volumes, and function of both ventricles. RESULTS: Determined using 1.5T CMR, the 
      native left ventricular (LV) septal T1 time averaged 1011 (range 973-1046) ms in 
      20 patients with RA vs. 976 (range 970-988) ms in 10 control subjects (p=0.045). 
      With 3T CMR, the T1 time measured 1173 (range 1154-1187) ms in 29 RA patients vs. 
      1053 (range 942-1148) ms in 9 control subjects (p=0.002). Myocardial LGE was 
      detected in 55% of the RA patients. LV ejection fraction averaged 58 (range 
      56-61)% vs. 66 (61-74)% (p<0.001) in the RA (n=60) and control groups (n=21), 
      respectively, and corresponding means for LV peak filling rate were 2.99 (range 
      2.32-3.33) s-1 vs. 3.39 (range 2.96-3.70) s-1 (p=0.012). The end-diastolic 
      volumes of either ventricle were enlarged in RA compared to the control group 
      (p<0.05 for both). CONCLUSIONS: In active RA, myocardial T1 relaxation times are 
      prolonged suggesting diffuse inflammation or fibrosis. Local myocardial scars and 
      inflammation, visible as LGE, are also common, as are impairments of LV 
      systo-diastolic function.
FAU - Holmstrom, Miia
AU  - Holmstrom M
AD  - HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland. miia.holmstrom@hus.fi.
FAU - Koivuniemi, Riitta
AU  - Koivuniemi R
AD  - Department of Rheumatology, University of Helsinki and Helsinki University 
      Hospital, Helsinki, Finland.
FAU - Korpi, Kirsi
AU  - Korpi K
AD  - Heart and Lung Center, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Kaasalainen, Touko
AU  - Kaasalainen T
AD  - HUS Medical Imaging Center, Clinical Physiology and Nuclear Medicine, University 
      of Helsinki and Helsinki University Hospital, Helsinki, Finland.
FAU - Laine, Mika
AU  - Laine M
AD  - Heart and Lung Center, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Kuuliala, Antti
AU  - Kuuliala A
AD  - Department of Bacteriology and Immunology, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland.
FAU - Leirisalo-Repo, Marjatta
AU  - Leirisalo-Repo M
AD  - Department of Rheumatology, University of Helsinki and Helsinki University 
      Hospital, Helsinki, Finland.
FAU - Kupari, Markku
AU  - Kupari M
AD  - Heart and Lung Center, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
FAU - Kivisto, Sari
AU  - Kivisto S
AD  - HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20160406
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Aged
MH  - *Arthritis, Rheumatoid/complications/diagnosis/epidemiology/physiopathology
MH  - Case-Control Studies
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Finland/epidemiology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Middle Aged
MH  - Patient Acuity
MH  - Stroke Volume
MH  - Time
MH  - *Ventricular Dysfunction, Left/diagnosis/etiology/physiopathology
EDAT- 2016/04/07 06:00
MHDA- 2016/08/06 06:00
CRDT- 2016/04/07 06:00
PHST- 2015/07/15 00:00 [received]
PHST- 2015/10/12 00:00 [accepted]
PHST- 2016/04/07 06:00 [entrez]
PHST- 2016/04/07 06:00 [pubmed]
PHST- 2016/08/06 06:00 [medline]
AID - 9729 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2016 May-Jun;34(3):416-23. Epub 2016 Apr 6.