PMID- 27051043 OWN - NLM STAT- MEDLINE DCOM- 20171002 LR - 20220311 IS - 1567-7257 (Electronic) IS - 1567-1348 (Linking) VI - 41 DP - 2016 Jul TI - Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population. PG - 177-184 LID - S1567-1348(16)30122-8 [pii] LID - 10.1016/j.meegid.2016.03.034 [doi] AB - Human leukocyte antigen (HLA) DPA1/DPB1 variants have been reported to influence Hepatitis B virus (HBV) infection. HLA-DPA1/DPB1 plays a pivotal role in antigen presentation to CD4(+) helper T cells and influences the outcome of HBV infection. To investigate the influence of HLA-DP variants on the outcome of HBV infection in an Indonesian population where it has the third-highest prevalence of HBV infection worldwide, we performed a case-control study of 686 participants, including patients with HBV-related advanced or nonadvanced liver disease, patients with spontaneously resolved HBV, and healthy controls. Single-nucleotide polymorphisms in HLA-DPA1 (rs3077) and HLA-DPB1 (rs3135021, rs9277535, and rs228388) were genotyped using real-time TaqMan(R) genotyping assays. Because rs2281388 deviated from Hardy-Weinberg equilibrium, it was excluded from subsequent analyses. The results of logistic regression analyses showed that the HLA-DPB1 rs9277535 variants were associated with a reduced risk of persistent HBV infection (odds ratio [OR] 0.70, 95% confidence interval [95% CI] 0.52-0.96, P=0.026, additive genetic model; OR 0.60, 95% CI 0.38-0.96, P=0.033, dominant genetic model). The HLA-DPA1 rs3077 variant was associated with a protective effect increasing the spontaneously resolved HBV infection (OR 0.64, 95% CI 0.41-0.98, P=0.039, dominant genetic model). By contrast, the HLA-DPB1 rs3135021 variant was not associated with the outcome of HBV infection, including susceptibility, spontaneously resolved, or disease progression. Combinations of haplotype markers were also associated with HBV susceptibility (CA for rs3077-rs9277535, OR 0.57, 95% CI 0.36-0.92, P=0.021; GA for rs3135021-rs9277535, OR 0.56, 95% CI 0.36-0.86, P=0.0087). In conclusion, these findings confirm that HLA-DPA1/DPB1 variants were associated with the outcomes of HBV infection in an Indonesian population. CI - Copyright (c) 2016 Elsevier B.V. All rights reserved. FAU - Wasityastuti, Widya AU - Wasityastuti W AD - Division of Molecular Medicine & Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Division of Infectious Disease Pathology, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Department of Physiology, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55281, Indonesia. FAU - Yano, Yoshihiko AU - Yano Y AD - Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. Electronic address: yanoyo@med.kobe-u.ac.jp. FAU - Ratnasari, Neneng AU - Ratnasari N AD - Subdivision of Gastroenterohepatology, Department of Internal Medicine, Dr. Sardjito Hospital, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55281, Indonesia. FAU - Triyono, Teguh AU - Triyono T AD - Department of Clinical Pathology, Dr. Sardjito Hospital, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55281, Indonesia. FAU - Triwikatmani, Catharina AU - Triwikatmani C AD - Subdivision of Gastroenterohepatology, Department of Internal Medicine, Dr. Sardjito Hospital, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55281, Indonesia. FAU - Indrarti, Fahmi AU - Indrarti F AD - Subdivision of Gastroenterohepatology, Department of Internal Medicine, Dr. Sardjito Hospital, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55281, Indonesia. FAU - Heriyanto, Didik Setyo AU - Heriyanto DS AD - Department of Anatomical Pathology, Dr. Sardjito Hospital, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55281, Indonesia. FAU - Yamani, Laura Navika AU - Yamani LN AD - Division of Molecular Medicine & Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Division of Infectious Disease Pathology, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. FAU - Liang, Yujiao AU - Liang Y AD - Division of Molecular Medicine & Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Division of Infectious Disease Pathology, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. FAU - Utsumi, Takako AU - Utsumi T AD - Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Indonesia-Japan Collaborative Research Centre for Emerging and Re-emerging Infectious Disease, Institute of Tropical Disease, Airlangga University, Surabaya 60115, Indonesia. FAU - Hayashi, Yoshitake AU - Hayashi Y AD - Division of Molecular Medicine & Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Division of Infectious Disease Pathology, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160402 PL - Netherlands TA - Infect Genet Evol JT - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JID - 101084138 RN - 0 (HLA-DP alpha-Chains) RN - 0 (HLA-DP beta-Chains) RN - 0 (HLA-DPA1 antigen) RN - 0 (HLA-DPB1 antigen) SB - IM MH - Adult MH - Alleles MH - Case-Control Studies MH - Female MH - Gene Expression MH - Gene Frequency MH - Genetic Predisposition to Disease MH - HLA-DP alpha-Chains/*genetics/immunology MH - HLA-DP beta-Chains/*genetics/immunology MH - Haplotypes MH - Hepatitis B virus/*genetics/growth & development/isolation & purification MH - Hepatitis B, Chronic/*genetics/immunology/virology MH - Humans MH - Indonesia MH - Male MH - Middle Aged MH - *Models, Genetic MH - *Polymorphism, Single Nucleotide MH - Protective Factors MH - Remission, Spontaneous MH - Severity of Illness Index OTO - NOTNLM OT - HBV infection OT - HLA-DP variants OT - Host gene OT - Indonesian population OT - Protection EDAT- 2016/04/07 06:00 MHDA- 2017/10/03 06:00 CRDT- 2016/04/07 06:00 PHST- 2015/09/12 00:00 [received] PHST- 2016/03/07 00:00 [revised] PHST- 2016/03/30 00:00 [accepted] PHST- 2016/04/07 06:00 [entrez] PHST- 2016/04/07 06:00 [pubmed] PHST- 2017/10/03 06:00 [medline] AID - S1567-1348(16)30122-8 [pii] AID - 10.1016/j.meegid.2016.03.034 [doi] PST - ppublish SO - Infect Genet Evol. 2016 Jul;41:177-184. doi: 10.1016/j.meegid.2016.03.034. Epub 2016 Apr 2.