PMID- 27051243
OWN - NLM
STAT- MEDLINE
DCOM- 20161220
LR  - 20181113
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 31
IP  - 4
DP  - 2016 Apr
TI  - Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of 
      Atherosclerosis-induced Chronic Pelvic Ischemia.
PG  - 585-9
LID - 10.3346/jkms.2016.31.4.585 [doi]
AB  - The aim of this study was to investigate whether the omega-3 fatty acids help to 
      improve erectile function in an atherosclerosis-induced erectile dysfunction rat 
      model. A total of 20 male Sprague-Dawley rats at age 8 weeks were divided into 
      three groups: Control group (n = 6, untreated sham operated rats), Pathologic 
      group (n = 7, untreated rats with chronic pelvic ischemia [CPI]), and Treatment 
      group (n = 7, CPI rats treated with omega-3 fatty acids). For the in vivo study, 
      electrical stimulation of the cavernosal nerve was performed and erectile 
      function was measured in all groups. Immunohistochemical antibody staining was 
      performed for transforming growth factor beta-1 (TGF-beta1), endothelial nitric 
      oxide synthase (eNOS), and hypoxia inducible factor 1-alpha (HIF-1alpha). In vivo 
      measurement of erectile function in the Pathologic group showed significantly 
      lower values than those in the Control group, whereas the Treatment group showed 
      significantly improved values in comparison with those in the Pathologic group. 
      The results of western blot analysis revealed that systemically administered 
      omega-3 fatty acids ameliorated the cavernosal molecular environment. Our study 
      suggests that omega-3 fatty acids improve intracavernosal pressure and have a 
      beneficial role against pathophysiological consequences such as fibrosis or 
      hypoxic damage on a CPI rat model, which represents a structural erectile 
      dysfunction model.
FAU - Shim, Ji Sung
AU  - Shim JS
AUID- ORCID: 0000-0002-6745-1776
AD  - Department of Urology, Korea University College of Medicine, Seoul, Korea .
FAU - Kim, Dae Hee
AU  - Kim DH
AD  - Department of Urology, Korea University College of Medicine, Seoul, Korea .
FAU - Bae, Jae Hyun
AU  - Bae JH
AD  - Department of Urology, Korea University College of Medicine, Seoul, Korea .
FAU - Moon, Du Geon
AU  - Moon du G
AUID- ORCID: 0000-0002-9031-9845
AD  - Department of Urology, Korea University College of Medicine, Seoul, Korea .
LA  - eng
PT  - Journal Article
DEP - 20160222
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Hif1a protein, rat)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Transforming Growth Factor beta1)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
CIN - J Korean Med Sci. 2017 Dec;32(12 ):2085-2086. PMID: 29115096
MH  - Animals
MH  - Atherosclerosis/*complications
MH  - Blotting, Western
MH  - Carotid Arteries/physiology
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Electric Stimulation
MH  - Fatty Acids, Omega-3/*pharmacology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Ischemia/etiology/*pathology
MH  - Male
MH  - Nitric Oxide Synthase Type III/metabolism
MH  - Penile Erection/*drug effects
MH  - Penis/metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transforming Growth Factor beta1/metabolism
PMC - PMC4810342
OTO - NOTNLM
OT  - Erectile Dysfunction
OT  - Fatty Acids, Omega-3
OT  - Ischemia
OT  - Rats
COIS- DISCLOSURE: The authors have no potential conflicts of interest to disclose.
EDAT- 2016/04/07 06:00
MHDA- 2016/12/21 06:00
PMCR- 2016/04/01
CRDT- 2016/04/07 06:00
PHST- 2015/09/13 00:00 [received]
PHST- 2015/12/23 00:00 [accepted]
PHST- 2016/04/07 06:00 [entrez]
PHST- 2016/04/07 06:00 [pubmed]
PHST- 2016/12/21 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.3346/jkms.2016.31.4.585 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2016 Apr;31(4):585-9. doi: 10.3346/jkms.2016.31.4.585. Epub 
      2016 Feb 22.