PMID- 27051441
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160407
LR  - 20200930
IS  - 1738-6055 (Print)
IS  - 2233-7660 (Electronic)
IS  - 1738-6055 (Linking)
VI  - 32
IP  - 1
DP  - 2016 Mar
TI  - Therapeutic effect of ethyl acetate extract from Asparagus cochinchinensis on 
      phthalic anhydride-induced skin inflammation.
PG  - 34-45
LID - 10.5625/lar.2016.32.1.34 [doi]
AB  - Asparagus cochinchinensis has been used to treat various diseases including 
      fever, cough, kidney disease, breast cancer, inflammatory disease and brain 
      disease, while IL-4 cytokine has been considered as key regulator on the skin 
      homeostasis and the predisposition toward allergic skin inflammation. However, 
      few studies have investigated its effects and IL-4 correlation on skin 
      inflammation to date. To quantitatively evaluate the suppressive effects of ethyl 
      acetate extracts of A. cochinchinensis (EaEAC) on phthalic anhydride (PA)-induced 
      skin inflammation and investigate the role of IL-4 during their action mechanism, 
      alterations in general phenotype biomarkers and luciferase-derived signals were 
      measured in IL-4/Luc/CNS-1 transgenic (Tg) mice with PA-induced skin inflammation 
      after treatment with EaEAC for 2 weeks. Key phenotype markers including lymph 
      node weight, immunoglobulin E (IgE) concentration, epidermis thickness and number 
      of infiltrated mast cells were significantly decreased in the PA+EaEAC treated 
      group compared with the PA+Vehicle treated group. In addition, expression of 
      IL-1beta and TNF-alpha was also decreased in the PA+EaEAC cotreated group, compared to 
      PA+Vehicle treated group. Furthermore, a significant decrease in the luciferase 
      signal derived from IL-4 promoter was detected in the abdominal region, 
      submandibular lymph node and mesenteric lymph node of the PA+EaEAC treated group, 
      compared to PA+Vehicle treated group. Taken together, these results suggest that 
      EaEAC treatment could successfully improve PA-induced skin inflammation of 
      IL-4/Luc/CNS-1 Tg mice, and that IL-4 cytokine plays a key role in the 
      therapeutic process of EaEAC.
FAU - Sung, Ji-Eun
AU  - Sung JE
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Lee, Hyun-Ah
AU  - Lee HA
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Kim, Ji-Eun
AU  - Kim JE
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Go, Jun
AU  - Go J
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Seo, Eun-Ji
AU  - Seo EJ
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Yun, Woo-Bin
AU  - Yun WB
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Kim, Dong-Seob
AU  - Kim DS
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Son, Hong-Joo
AU  - Son HJ
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
FAU - Lee, Chung-Yeoul
AU  - Lee CY
AD  - Gangrim Organics, Miryang 627-706, Korea.
FAU - Lee, Hee-Seob
AU  - Lee HS
AD  - College of Human Ecology, Pusan National University, Busan, Korea.
FAU - Hwang, Dae-Youn
AU  - Hwang DY
AD  - College of Natural Resources and Life Science/Life and Industry Convergence 
      Research Institute, Pusan National University, Miryang 627-706, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160324
PL  - England
TA  - Lab Anim Res
JT  - Laboratory animal research
JID - 101560684
PMC - PMC4816995
OTO - NOTNLM
OT  - Asparagus cochinchinensis
OT  - IL-4/Luc/CNS-1 transgenic mice
OT  - IgE
OT  - phthalic anhydride
OT  - skin inflammation
COIS- Conflict of interests: The authors declare that there is no financial conflict of 
      interests to publish these results.
EDAT- 2016/04/07 06:00
MHDA- 2016/04/07 06:01
PMCR- 2016/03/01
CRDT- 2016/04/07 06:00
PHST- 2016/02/02 00:00 [received]
PHST- 2016/02/28 00:00 [revised]
PHST- 2016/03/03 00:00 [accepted]
PHST- 2016/04/07 06:00 [entrez]
PHST- 2016/04/07 06:00 [pubmed]
PHST- 2016/04/07 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 10.5625/lar.2016.32.1.34 [doi]
PST - ppublish
SO  - Lab Anim Res. 2016 Mar;32(1):34-45. doi: 10.5625/lar.2016.32.1.34. Epub 2016 Mar 
      24.