PMID- 27051449
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160407
LR  - 20240325
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2016
DP  - 2016
TI  - A Transmembrane Polymorphism of Fcgamma Receptor IIb Is Associated with Kidney 
      Deficiency Syndrome in Rheumatoid Arthritis.
PG  - 3214657
LID - 10.1155/2016/3214657 [doi]
LID - 3214657
AB  - Objective. The purpose is to investigate the role of kidney deficiency and the 
      association between kidney deficiency and a polymorphism FcgammaRIIb 695T>C coding 
      for nonsynonymous substitution IIe232Thr (I232T) in rheumatoid arthritis (RA). 
      Methods. Clinical parameters and autoantibodies were analyzed and genotyping was 
      performed in 159 kidney deficiency and 161 non-kidney-deficiency RA patients. 
      Results. The age of disease onset and disease duration exhibited significant 
      differences between two groups (P < 0.01). Patients with kidney deficiency tend 
      to have higher activity of disease (P < 0.05). Anti-cyclic citrullinated peptides 
      antibodies (ACPA) levels of patients with kidney deficiency were higher than the 
      controls (P = 0.039). 125 (78.6%) kidney deficiency and 114 (70.8%) 
      non-kidney-deficiency patients had both ACPA-positive and RF-positive (P = 0.04, 
      OR = 3.29). FcgammaRIIb I232TT homozygotes were identified in 10 of 159 (6.3%) kidney 
      deficiency subjects and 1 of 161 (0.6%) controls (P = 0.000, OR = 16.45). 
      Furthermore, in pooled genotype analysis, I232IT and I232TT homozygotes were 
      significantly enriched in kidney deficiency individuals compared with the 
      controls (P = 0.000, OR = 3.79). Frequency of T allele was associated with kidney 
      deficiency RA population (P = 0.000, OR = 3.18). Conclusion. This study confirmed 
      that kidney deficiency was closely associated with disease activity and 
      autoimmune disorder in RA. Kidney deficiency in RA is first to reveal a strong 
      genetic link to FcgammaRIIb variants.
FAU - Mo, Na
AU  - Mo N
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
FAU - Lai, Ruogu
AU  - Lai R
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
FAU - Luo, Shizi
AU  - Luo S
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
FAU - Xie, Jianglin
AU  - Xie J
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
FAU - Wang, Xizi
AU  - Wang X
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
FAU - Liu, Lijuan
AU  - Liu L
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
FAU - Liu, Xiaoling
AU  - Liu X
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
FAU - Chen, Guangxing
AU  - Chen G
AUID- ORCID: 0000-0002-1102-6965
AD  - Division of Rheumatology and Clinical Immunology, The First Affiliated Hospital 
      of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
LA  - eng
PT  - Journal Article
DEP - 20160308
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4802036
EDAT- 2016/04/07 06:00
MHDA- 2016/04/07 06:01
PMCR- 2016/03/08
CRDT- 2016/04/07 06:00
PHST- 2015/12/06 00:00 [received]
PHST- 2016/02/07 00:00 [revised]
PHST- 2016/02/18 00:00 [accepted]
PHST- 2016/04/07 06:00 [entrez]
PHST- 2016/04/07 06:00 [pubmed]
PHST- 2016/04/07 06:01 [medline]
PHST- 2016/03/08 00:00 [pmc-release]
AID - 10.1155/2016/3214657 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2016;2016:3214657. doi: 10.1155/2016/3214657. 
      Epub 2016 Mar 8.