PMID- 27053619
OWN - NLM
STAT- MEDLINE
DCOM- 20160921
LR  - 20221207
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 32
IP  - 4
DP  - 2016 Apr
TI  - [Comparison of HLA-DRB1, HLA-DQB1 and HLA-DPB1 gene polymorphisms and haplotypes 
      in partial Han and Uyghur populations of Xinjiang region].
PG  - 518-22, 526
AB  - OBJECTIVE: To investigate the gene polymorphism and haplotype distribution 
      characteristics of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 in Han and 
      Uyghur populations from the Xinjiang Uyghur Autonomous Region. METHODS: The 
      polymerase chain reaction-sequencing-based typing (PCR-SBT) was applied to 
      analyze the HLA-DRB1, HLA-DQB1 and HLA-DPB1 genotypes in 188 Han and 90 Uyghur 
      individuals. The gene frequencies were calculated by direct counting method, and 
      the haplotype frequencies were obtained by the maximum likelihood method with 
      Arlequin3.5 software. RESULTS: In the 188 Han individuals, the most common 
      alleles were DRB1*09:01 (12.8%), DQB1*03:01 (20.3%) and DPB1*05:01 (33.5%); the 
      most common haplotypes were DRB1*09:01-DQB1*03:03 (8.8%), DRB1*09:01-DPB1*05:01 
      (5.0%), DQB1*03:01-DPB1*05:01 (9.6%) and DRB1*09:01-DQB1*03:03-DPB1*05:01 (6.3%). 
      In the 90 Uyghur individuals, the most common alleles were DRB1*07:01 (18.3%), 
      DQB1*03:01 (18.9%) and DPB1*04:01 (30%); the most common haplotypes were DRB1*07: 
      01-DQB1*02:02 (16.1%), DRB1*07:01-DPB1*04:01 (5.0%), DQB1*03:01-DPB1*04:01 (7.3%) 
      and DRB1*07:01-DQB1*02:02-DPB1*04:01 (7.4%). Alleles DRB1*04:04, DRB1*07: 01, 
      DRB1*08:03, DRB1*12: 02, DRB1*13:01, DRB1*15:01, DQB1*02:02, DQB1*06:01, 
      DPB1*04:01 and DPB1*05:01 were significantly different between the two groups. 
      CONCLUSION: Gene polymorphism and haplotype distributions of HLA-DRB1, HLA-DQB1 
      and HLA-DPB1 present their own characteristics in Xinjiang Han and Uyghur 
      populations.
FAU - Wu, Jiangdong
AU  - Wu J
AD  - Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases, 
      Shihezi University, Shihezi 832000, China. *Corresponding authors, E-mail: 
      wujiangdong@shzu.edu.cn.
FAU - Lu, Lijun
AU  - Lu L
AD  - Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases, 
      Shihezi University, Shihezi 832000, China. *Corresponding authors, E-mail: 
      lulijun2014@sina.com.
FAU - Zuo, Weize
AU  - Zuo W
AD  - Department of Infectious Diseases, First Affiliated Hospital, Medical College, 
      Shihezi University, Shihezi 832000, China.
FAU - Zhang, Le
AU  - Zhang L
AD  - Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases, 
      Shihezi University, Shihezi 832000, China.
LA  - chi
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/*ethnology/*genetics
MH  - China/ethnology
MH  - Female
MH  - Gene Frequency
MH  - HLA-DP beta-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Young Adult
EDAT- 2016/04/08 06:00
MHDA- 2016/09/23 06:00
CRDT- 2016/04/08 06:00
PHST- 2016/04/08 06:00 [entrez]
PHST- 2016/04/08 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Apr;32(4):518-22, 526.