PMID- 2705581
OWN - NLM
STAT- MEDLINE
DCOM- 19890512
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 256
IP  - 4 Pt 2
DP  - 1989 Apr
TI  - Renal denervation alters forebrain hexokinase activity in neurogenic hypertensive 
      rats.
PG  - R930-8
AB  - The effect of afferent renal nerve transection (tARN) on the metabolic activity 
      of forebrain structures the activity of which was altered after aortic depressor 
      nerve transection (tADN) was studied using the hexokinase (HK) histochemical 
      method in the rat. In tADN-sham (s) ARN rats, increases in HK activity were 
      observed in the medial septum (MS), median preoptic nucleus (MnPO), subfornical 
      organ, supraoptic nucleus, nucleus circularis (Nc), magnocellular, and dorsal and 
      medial (mpPVH) parvocellular components of paraventricular nucleus, the anterior, 
      lateral, and dorsomedial (DMH) hypothalamus, and in the central and medial nuclei 
      of the amygdala. In addition, a decrease in HK activity was seen in the dorsal 
      arcuate nucleus (dArc). Similarly, increases in HK activity were seen in 
      sADN-tARN rats in all the above structures except MS, Nc, and DMH, where no 
      changes were observed, and dArc, where an increase in HK activity was noted. The 
      bed nucleus of the stria terminalis, lateral preoptic nucleus (POA), and ventral 
      (v) Arc also showed elevated HK activity. In contrast, the increased HK activity 
      after either tADN or tARN alone was returned to levels not different from 
      sADN-sARN rats in all structures in the tADN-tARN rats, except MnPO, mpPVH, and 
      dArc, where the level of HK activity was only attenuated, and MS, POA, and vArc, 
      where it remained elevated. These data suggest that similar forebrain structure 
      are associated with the hypertension after tADN and are involved in the 
      integration of ARN information and that these sites of interaction are involved 
      in the maintenance and the reversal of the neurogenic hypertension.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Simon, J K
AU  - Simon JK
AD  - Department of Physiology, University of Western Ontario, London, Canada.
FAU - Zhang, T X
AU  - Zhang TX
FAU - Ciriello, J
AU  - Ciriello J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Blood Pressure
MH  - Brain/*enzymology
MH  - Denervation
MH  - Hexokinase/*metabolism
MH  - Hypertension/*enzymology
MH  - Kidney/*innervation
MH  - Male
MH  - Pressoreceptors/physiology
MH  - Rats
MH  - Reflex/physiology
MH  - Sympathetic Nervous System/physiology
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1152/ajpregu.1989.256.4.R930 [doi]
PST - ppublish
SO  - Am J Physiol. 1989 Apr;256(4 Pt 2):R930-8. doi: 10.1152/ajpregu.1989.256.4.R930.