PMID- 27056455
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20181202
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 11
IP  - 9
DP  - 2016 Sep
TI  - Neural signature of food reward processing in bulimic-type eating disorders.
PG  - 1393-401
LID - 10.1093/scan/nsw049 [doi]
AB  - Clinical observations and similarities to addiction suggest heightened reward 
      sensitivity to food in patients with bulimic-type eating (BTE) disorders. 
      Therefore, we investigated the expectation and receipt of food reward compared 
      with monetary reward in patients with BTE. Fifty-six patients with BTE (27 
      patients with binge eating disorder and 29 with bulimia nervosa) and 55 matched 
      healthy control participants underwent event-related functional magnetic 
      resonance imaging while performing both food and monetary incentive delay tasks. 
      BTE patients exhibited reduced brain activation in the posterior cingulate cortex 
      during the expectation of food and increased activity in the medial orbitofrontal 
      cortex, anterior medial prefrontal cortex and posterior cingulate cortex during 
      the receipt of food reward. These findings were relevant to food because we found 
      no significant group differences related to monetary reward. In the patients, 
      higher brain activity in the medial orbitofrontal cortex during the receipt of 
      food reward was related to higher levels of trait food craving and external 
      eating. BTE patients exhibited increased hedonic processing during the receipt of 
      food reward. These findings corroborate the notion that an altered responsiveness 
      of the reward network to food stimuli is associated with BTE.
CI  - (c) The Author (2016). Published by Oxford University Press. For Permissions, 
      please email: journals.permissions@oup.com.
FAU - Simon, Joe J
AU  - Simon JJ
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany 
      Department of Psychosomatic Medicine and Psychotherapy Medical Faculty, 
      Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany 
      joe.simon@med.uni-heidelberg.de.
FAU - Skunde, Mandy
AU  - Skunde M
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
FAU - Walther, Stephan
AU  - Walther S
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany 
      Department of General Adult Psychiatry, Centre for Psychosocial Medicine, 
      Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
FAU - Bendszus, Martin
AU  - Bendszus M
AD  - Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Herzog, Wolfgang
AU  - Herzog W
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
FAU - Friederich, Hans-Christoph
AU  - Friederich HC
AD  - Department of General Internal Medicine and Psychosomatics, Centre for 
      Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany 
      Department of Psychosomatic Medicine and Psychotherapy Medical Faculty, 
      Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160406
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
SB  - IM
MH  - Adult
MH  - Binge-Eating Disorder/psychology
MH  - Brain Mapping
MH  - Bulimia/*psychology
MH  - Female
MH  - *Food
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Hunger
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/physiopathology
MH  - Psychiatric Status Rating Scales
MH  - *Reward
MH  - Young Adult
PMC - PMC5015798
OTO - NOTNLM
OT  - binge eating disorder
OT  - bulimia nervosa
OT  - functional MRI
OT  - medial orbitofrontal cortex
OT  - posterior cingulate cortex
OT  - reward processing
EDAT- 2016/04/09 06:00
MHDA- 2017/10/24 06:00
PMCR- 2016/09/01
CRDT- 2016/04/09 06:00
PHST- 2015/11/04 00:00 [received]
PHST- 2016/03/31 00:00 [accepted]
PHST- 2016/04/09 06:00 [entrez]
PHST- 2016/04/09 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - nsw049 [pii]
AID - 10.1093/scan/nsw049 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2016 Sep;11(9):1393-401. doi: 10.1093/scan/nsw049. Epub 
      2016 Apr 6.