PMID- 27056853
OWN - NLM
STAT- MEDLINE
DCOM- 20160725
LR  - 20160408
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 68
IP  - 4
DP  - 2016 Apr
TI  - [Neuro-neutrophilic Disease and Dementia].
PG  - 353-64
LID - 10.11477/mf.1416200405 [doi]
AB  - Neuro-neutrophilic diseases are multisystem inflammatory disorders that include 
      neuro-Behcet and neuro-Sweet disease. These disorders ectopically damage the 
      nervous system due to the abnormal chemotaxis of neutrophils. The neutrophils' 
      chemotaxis is induced by oral muco-cutaneous bacterial infections and the 
      dysregulation of cytokines, including interleukins. The frequencies of human 
      leukocyte antigen (HLA)-B51 in neuro-Behcet disease and HLA-B54 as well as Cw1 in 
      neuro-Sweet disease significantly higher than the levels present in Japanese 
      normal controls. Notably, their frequencies are also higher in patients 
      exhibiting neurological complications than in patients without neurological 
      complications. These HLA types are considered risk factors that are directly 
      related to the etiology of these diseases. Prednisolone and colchicine, which 
      suppress neutrophil activation, are used to treat the acute phase of both 
      diseases. Alternatively, dapsone is prescribed to prednisolone-dependent 
      recurrent cases of neuro-Sweet disease. Dementia is a neurological symptom of 
      these disorders, especially in the chronic progressive subtype of neuro-Behcet 
      disease. Other immunosuppressant drugs, including methotrexate and infliximab, 
      are administered to patients with the chronic progressive type of neuro-Behcet 
      disease. Neuro-neutrophilic diseases are a form of dementia considered treatable.
FAU - Hisanaga, Kinya
AU  - Hisanaga K
AD  - Departments of Neurology and Clinical Research Center, National Hospital 
      Organization, Miyagi Hospital.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Animals
MH  - Behcet Syndrome/diagnosis/drug therapy
MH  - Dementia/complications/diagnosis/*drug therapy/immunology
MH  - Humans
MH  - Japan
MH  - Neutrophils/*drug effects
MH  - *Practice Guidelines as Topic
MH  - Prednisolone/*pharmacology
MH  - Sweet Syndrome/complications/diagnosis/*drug therapy/immunology
EDAT- 2016/04/09 06:00
MHDA- 2016/07/28 06:00
CRDT- 2016/04/09 06:00
PHST- 2016/04/09 06:00 [entrez]
PHST- 2016/04/09 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 1416200405 [pii]
AID - 10.11477/mf.1416200405 [doi]
PST - ppublish
SO  - Brain Nerve. 2016 Apr;68(4):353-64. doi: 10.11477/mf.1416200405.