PMID- 27056866
OWN - NLM
STAT- MEDLINE
DCOM- 20160725
LR  - 20160408
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 68
IP  - 4
DP  - 2016 Apr
TI  - [Progressive Multifocal Leukoencephalopathy with Inflammatory Reactions].
PG  - 479-88
LID - 10.11477/mf.1416200422 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder 
      caused by reactivation of the JC virus associated with impaired host immunity. 
      However, PML may occur even without an evident cause of immunosuppression. In 
      such cases, JC virus DNA in cerebrospinal fluid (CSF) may not be detectable with 
      polymerase chain reactions (PCR), and a brain biopsy may be performed. Pathology 
      may exhibit marked inflammatory reactions around the JC virus-infected cells, 
      although typical intranuclear viral inclusions would rarely be seen. Atypical 
      inflammation in patients with PML likely an indication of the host's 
      immune-response against the virus. this is usually observed in those with 
      relatively-mild immunosuppression with favorable prognosis. Here, we describe 
      cases of PML that exhibited inflammatory reactions; a recent topic, PML with 
      immune reconstruction inflammatory syndrome (IRIS), will also be discussed.
FAU - Shishido-Hara, Yukiko
AU  - Shishido-Hara Y
AD  - Physician, Student, Researcher Support Center/Department of Anatomic Pathology, 
      Tokyo Medical University.
FAU - Uchihara, Toshiki
AU  - Uchihara T
FAU - Sanjo, Nobuo
AU  - Sanjo N
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
SB  - IM
MH  - AIDS-Related Opportunistic Infections/complications/diagnosis/*pathology
MH  - Biopsy/methods
MH  - Brain/*pathology
MH  - Demyelinating Diseases/complications/diagnosis/*pathology
MH  - Humans
MH  - Inflammation/complications/diagnosis/pathology
MH  - Leukoencephalopathy, Progressive Multifocal/complications/diagnosis/*pathology
EDAT- 2016/04/09 06:00
MHDA- 2016/07/28 06:00
CRDT- 2016/04/09 06:00
PHST- 2016/04/09 06:00 [entrez]
PHST- 2016/04/09 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 1416200422 [pii]
AID - 10.11477/mf.1416200422 [doi]
PST - ppublish
SO  - Brain Nerve. 2016 Apr;68(4):479-88. doi: 10.11477/mf.1416200422.