PMID- 27057174 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160408 LR - 20220409 IS - 1687-966X (Print) IS - 1687-9678 (Electronic) VI - 2016 DP - 2016 TI - Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications. PG - 6737345 LID - 10.1155/2016/6737345 [doi] LID - 6737345 AB - Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment, which benefits the localization, attachment, proliferation, and differentiation of ASCs. Therefore, tissue-engineered ASCs are recognized as an attractive substitute for tissue and organ transplantation. In this paper, we review the characteristics of ASCs, as well as the biomaterials and tissue engineering methods used to proliferate and differentiate ASCs in a 3D environment. Clinical applications of tissue-engineered ASCs are also discussed to reveal the potential and feasibility of using tissue-engineered ASCs in regenerative medicine. FAU - Dai, Ru AU - Dai R AD - School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7; West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. FAU - Wang, Zongjie AU - Wang Z AD - School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7. FAU - Samanipour, Roya AU - Samanipour R AD - School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7. FAU - Koo, Kyo-In AU - Koo KI AD - Department of Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of Korea. FAU - Kim, Keekyoung AU - Kim K AD - School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7. LA - eng PT - Journal Article PT - Review DEP - 20160221 PL - United States TA - Stem Cells Int JT - Stem cells international JID - 101535822 PMC - PMC4761677 EDAT- 2016/04/09 06:00 MHDA- 2016/04/09 06:01 PMCR- 2016/02/21 CRDT- 2016/04/09 06:00 PHST- 2015/10/16 00:00 [received] PHST- 2016/01/02 00:00 [revised] PHST- 2016/01/03 00:00 [accepted] PHST- 2016/04/09 06:00 [entrez] PHST- 2016/04/09 06:00 [pubmed] PHST- 2016/04/09 06:01 [medline] PHST- 2016/02/21 00:00 [pmc-release] AID - 10.1155/2016/6737345 [doi] PST - ppublish SO - Stem Cells Int. 2016;2016:6737345. doi: 10.1155/2016/6737345. Epub 2016 Feb 21.