PMID- 27057748 OWN - NLM STAT- MEDLINE DCOM- 20170321 LR - 20211020 IS - 1878-3511 (Electronic) IS - 1201-9712 (Linking) VI - 46 DP - 2016 May TI - Herpesvirus infections in hematopoietic stem cell transplant recipients seropositive for human cytomegalovirus before transplantation. PG - 89-93 LID - S1201-9712(16)31013-X [pii] LID - 10.1016/j.ijid.2016.03.025 [doi] AB - BACKGROUND: Viral infections are a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The effect of herpesvirus infections in human cytomegalovirus (HCMV)-seropositive (IgG-positive/IgM-negative) HSCT recipients remains poorly understood. The risk factors associated with Epstein-Barr virus (EBV), HCMV, and human herpes virus type 6 (HHV-6) infections after HSCT, both alone and in combination, were investigated in this study. METHODS: Peripheral blood specimens were collected from 44 HSCT recipients and examined for viral DNA using quantitative fluorescence PCR assays. Risk factors for EBV, HCMV, and HHV-6 infections were analyzed by binary logistic regression, and relationships between these viruses were analyzed using the Chi-square test. RESULTS: EBV, HCMV, and HHV-6 were detected in 50%, 45.45%, and 25% of HCMV-seropositive (IgG-positive/IgM-negative) HSCT recipients, respectively. Male sex (p=0.007) and conditioning regimens including anti-thymocyte globulin (ATG) (p=0.034) were strongly associated with an increased risk of EBV infection. Graft-versus-host disease (GVHD) prophylaxis with corticosteroids was a risk factor for both EBV (p=0.013) and HCMV (p=0.040) infections, while EBV infection (p=0.029) was found to be an independent risk factor for HHV-6 infection. Pre-existing HHV-6 infection was associated with lower rates of HCMV infection (p=0.002); similarly, pre-existing HCMV infection was protective against HHV-6 infection (p=0.036). CONCLUSIONS: HCMV-seropositive (IgG-positive/IgM-negative) HSCT recipients exhibited a high rate of herpesvirus infections, particularly EBV. ATG and male sex were strongly associated with an increased risk of EBV infection. GVHD prophylaxis with prednisone was found to affect both EBV and HCMV infections. Prior infection with EBV was shown to promote HHV-6 infection. Taken together, these data highlight the need for active monitoring of herpesvirus infections in patients undergoing HSCT. CI - Copyright (c) 2016 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Fan, Jun AU - Fan J AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Jing, Min AU - Jing M AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Yang, Meifang AU - Yang M AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Xu, Lichen AU - Xu L AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Liang, Hanying AU - Liang H AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Huang, Yaping AU - Huang Y AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Yang, Rong AU - Yang R AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Gui, Genyong AU - Gui G AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Wang, Huiqi AU - Wang H AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Gong, Shengnan AU - Gong S AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Wang, Jindong AU - Wang J AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Zhang, Xuan AU - Zhang X AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Zhao, Hong AU - Zhao H AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Gao, Hainv AU - Gao H AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Dong, Huihui AU - Dong H AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Ma, Weihang AU - Ma W AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. FAU - Hu, Jianhua AU - Hu J AD - State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China. Electronic address: hjianhua0825@126.com. LA - eng PT - Journal Article DEP - 20160404 PL - Canada TA - Int J Infect Dis JT - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JID - 9610933 RN - 0 (Antibodies, Viral) SB - IM MH - Adolescent MH - Adult MH - Antibodies, Viral/blood MH - Cytomegalovirus/genetics/*immunology/isolation & purification MH - Cytomegalovirus Infections/blood/etiology/*virology MH - Epstein-Barr Virus Infections/blood/etiology/*virology MH - Female MH - Hematopoietic Stem Cell Transplantation/*adverse effects MH - Herpesviridae Infections/blood/etiology/*virology MH - Humans MH - Male MH - Middle Aged MH - Postoperative Complications/blood/etiology/*virology MH - Transplant Recipients/statistics & numerical data MH - Young Adult OTO - NOTNLM OT - Epstein-Barr virus OT - Hematopoietic stem cell transplantation OT - Herpesvirus OT - Human cytomegalovirus OT - Human herpes virus type 6 OT - Infection EDAT- 2016/04/09 06:00 MHDA- 2017/03/23 06:00 CRDT- 2016/04/09 06:00 PHST- 2016/01/06 00:00 [received] PHST- 2016/03/08 00:00 [revised] PHST- 2016/03/30 00:00 [accepted] PHST- 2016/04/09 06:00 [entrez] PHST- 2016/04/09 06:00 [pubmed] PHST- 2017/03/23 06:00 [medline] AID - S1201-9712(16)31013-X [pii] AID - 10.1016/j.ijid.2016.03.025 [doi] PST - ppublish SO - Int J Infect Dis. 2016 May;46:89-93. doi: 10.1016/j.ijid.2016.03.025. Epub 2016 Apr 4.