PMID- 27058358
OWN - NLM
STAT- MEDLINE
DCOM- 20171109
LR  - 20171206
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 14
IP  - 5
DP  - 2016 Jun
TI  - The Best Obesity Indices to Discriminate Type 2 Diabetes Mellitus.
PG  - 249-53
LID - 10.1089/met.2015.0133 [doi]
AB  - BACKGROUND: It is expected that the number of people with diabetes will reach 435 
      million by 2030. Obesity is considered the most important predictor of type 2 
      diabetes mellitus (T2DM). We conducted the present study to determine the best 
      usual discriminator indices of obesity to diagnose diabetes mellitus (DM). 
      METHODS: Of 6143 subjects aged 10-90 years from a baseline cohort study, the data 
      of 5772 participants aged >18 years and without history of type 1 diabetes were 
      utilized to analyze in this study. The cohort study was carried out in northern 
      Iran and sampling frame was provided from related local health centers. The 
      capability of obesity indices, including body mass index (BMI), waist 
      circumference (WC), waist-to-hip ratio (WHR), and body adiposity index (BAI), in 
      the discrimination of DM was evaluated. Discriminatory capabilities were 
      evaluated using the receiver operating characteristic (ROC) curve. Logistic 
      regression analysis was performed to determine the strength of association 
      between obesity indices and DM. RESULTS: The areas under ROC curve of BAI, BMI, 
      WC, and WHR were 0.6244 (0.5918-0.6570), 0.6214 (0.5908-0.6520), 0.6636 
      (0.6341-0.6930), and 0.7303 (0.7032-0.7575) in men and 0.5961 (0.5674-0.6249), 
      0.5963 (0.5690-0.6235), 0.6850 (0.6593-0.7108), and 0.7529 (0.7297-0.7761) in 
      women, respectively. In the multivariate model, one unit increase in Z-score of 
      BMI, WC, and WHR increased the chance of DM by 49%, 65%, and 51% in men and by 
      17%, 51%, and 67% in women, respectively. No association was found between DM and 
      BAI in this model. CONCLUSIONS: While WHR had an appropriate discriminatory 
      capability for T2DM in the population of northern Iran, BAI and BMI did not.
FAU - Motamed, Nima
AU  - Motamed N
AD  - 1 Department of Social Medicine, Zanjan University of Medical Sciences , Zanjan, 
      Iran .
FAU - Rabiee, Behnam
AU  - Rabiee B
AD  - 2 Gastroenterology and Liver Disease Research Center, Iran University of Medical 
      Sciences , Firoozgar Hospital, Tehran, Iran .
FAU - Keyvani, Hossein
AU  - Keyvani H
AD  - 3 Department of Virology, Iran University of Medical Sciences , Tehran, Iran .
FAU - Hemasi, Gholam Reza
AU  - Hemasi GR
AD  - 2 Gastroenterology and Liver Disease Research Center, Iran University of Medical 
      Sciences , Firoozgar Hospital, Tehran, Iran .
FAU - Khonsari, Mahmood
AU  - Khonsari M
AD  - 2 Gastroenterology and Liver Disease Research Center, Iran University of Medical 
      Sciences , Firoozgar Hospital, Tehran, Iran .
FAU - Saeedian, Fatemeh Sima
AU  - Saeedian FS
AD  - 2 Gastroenterology and Liver Disease Research Center, Iran University of Medical 
      Sciences , Firoozgar Hospital, Tehran, Iran .
FAU - Maadi, Mansooreh
AU  - Maadi M
AD  - 2 Gastroenterology and Liver Disease Research Center, Iran University of Medical 
      Sciences , Firoozgar Hospital, Tehran, Iran .
FAU - Zamani, Farhad
AU  - Zamani F
AD  - 2 Gastroenterology and Liver Disease Research Center, Iran University of Medical 
      Sciences , Firoozgar Hospital, Tehran, Iran .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160408
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
SB  - IM
MH  - Adiposity
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Child
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/*complications
MH  - ROC Curve
MH  - Regression Analysis
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Waist Circumference
MH  - Waist-Hip Ratio
MH  - Young Adult
EDAT- 2016/04/09 06:00
MHDA- 2017/11/10 06:00
CRDT- 2016/04/09 06:00
PHST- 2016/04/09 06:00 [entrez]
PHST- 2016/04/09 06:00 [pubmed]
PHST- 2017/11/10 06:00 [medline]
AID - 10.1089/met.2015.0133 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2016 Jun;14(5):249-53. doi: 10.1089/met.2015.0133. Epub 
      2016 Apr 8.