PMID- 27059393
OWN - NLM
STAT- MEDLINE
DCOM- 20170601
LR  - 20170601
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 9
IP  - 3
DP  - 2017 Mar
TI  - Outpatient measurement of arterial stiffness in patients with type 2 diabetes and 
      obesity.
PG  - 237-242
LID - 10.1111/1753-0407.12405 [doi]
AB  - BACKGROUND: Pulse wave velocity (PWV) is a marker of arterial stiffness. The aim 
      of the present study was to compare PWV in patients with type 2 diabetes mellitus 
      (T2DM) or obesity and healthy subjects in an outpatient setting. METHODS: A 
      cross-sectional study was conducted in patients with obesity without T2DM 
      (n = 37), T2DM without obesity (n = 40), T2DM plus obesity (n = 43), and healthy 
      controls (n = 114). Outpatient measurements of the finger-toe PWV (ftPWV) were 
      made. RESULTS: Mean (+/- SD) ftPWV was higher in men than in women (10.57 +/- 5.02 vs 
      9.14 +/- 3.68 m/s, respectively P = 0.006) and was positively correlated with age 
      (r(2)  = 0.31, P < 0.0001), body mass index (r(2)  = 0.03, P = 0.01), systolic 
      blood pressure (SBP; r(2)  = 0.06, P < 0.0001), and right (r(2)  = 0.03, 
      P = 0.01) and left (r(2)  = 0.03, P = 0.01) ankle-brachial index (ABI). Age, SBP 
      and ABI remained significantly correlated with ftPWV in the stepwise regression 
      analysis. Mean ftPWV in controls and in patients with obesity, T2DM, and T2DM 
      plus obesity was 8.32 +/- 2.68, 9.50 +/- 3.38, 11.29 +/- 4.34, and 12.36 +/- 6.67 m/s, 
      respectively (P < 0.0001). These differences remained significant after 
      adjustments for sex, age, SBP, and ABI (P = 0.008). Although ftPWV was higher in 
      patients with than without macrovascular complications (13.11 +/- 6.25 vs 
      10.40 +/- 4.54 m/s, respectively; P = 0.006) in univariate analysis, this was not 
      so in the multivariate-adjusted model. CONCLUSIONS: Outpatient-measured ftPWV was 
      correlated with age, SBP, and ABI. It was higher in patients with T2DM and 
      obesity compared with healthy controls. The highest ftPWV was observed in 
      patients with both T2DM and obesity.
CI  - (c) 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Mohammedi, Kamel
AU  - Mohammedi K
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
FAU - Compaore, Aminata
AU  - Compaore A
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
FAU - Potier, Louis
AU  - Potier L
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, UFR de Medecine, Paris, France.
FAU - Belhatem, Narimene
AU  - Belhatem N
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
FAU - Feron, Marilyne
AU  - Feron M
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
FAU - Matallah, Nadia
AU  - Matallah N
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
FAU - Travert, Florence
AU  - Travert F
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, UFR de Medecine, Paris, France.
FAU - Hansel, Boris
AU  - Hansel B
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, UFR de Medecine, Paris, France.
FAU - Velho, Gilberto
AU  - Velho G
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
FAU - Roussel, Ronan
AU  - Roussel R
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, UFR de Medecine, Paris, France.
FAU - Hallab, Magid
AU  - Hallab M
AD  - Department of Gerontology, University Hospital of Nantes, Nantes, France.
FAU - Marre, Michel
AU  - Marre M
AD  - INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
AD  - Assistance Publique Hopitaux de Paris, Bichat Hospital, DHU FIRE, Department of 
      Diabetology, Endocrinology and Nutrition, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris Cite, UFR de Medecine, Paris, France.
LA  - eng
PT  - Journal Article
TT  - 2型糖尿病与肥胖患者在门诊测量的动脉硬化度.
DEP - 20160728
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*physiopathology
MH  - Outpatients/*statistics & numerical data
MH  - *Pulse Wave Analysis
MH  - Regression Analysis
MH  - Risk Factors
MH  - *Vascular Stiffness
OTO - NOTNLM
OT  - Obesity
OT  - pulse wave velocity
OT  - type 2 diabetes
OT  - vascular stiffness
OT  - 肥胖,脉搏波速度,2型糖尿病,血管硬化
EDAT- 2016/04/10 06:00
MHDA- 2017/06/02 06:00
CRDT- 2016/04/10 06:00
PHST- 2015/07/18 00:00 [received]
PHST- 2016/02/17 00:00 [revised]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/04/10 06:00 [pubmed]
PHST- 2017/06/02 06:00 [medline]
PHST- 2016/04/10 06:00 [entrez]
AID - 10.1111/1753-0407.12405 [doi]
PST - ppublish
SO  - J Diabetes. 2017 Mar;9(3):237-242. doi: 10.1111/1753-0407.12405. Epub 2016 Jul 
      28.