PMID- 27059731
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20220330
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 37
IP  - 6
DP  - 2016 Jun
TI  - The HLA-DRB1 allele polymorphisms and nasopharyngeal carcinoma.
PG  - 7119-28
LID - 10.1007/s13277-016-5051-9 [doi]
AB  - Human leukocyte antigen (HLA)-DRB1 has been reported to influence individual's 
      susceptibility to nasopharyngeal carcinoma (NPC) by many studies in recent years; 
      however, these studies provided controversial results. The meta-analysis was thus 
      conducted here to estimate the relationship between HLA-DRB1 polymorphisms and 
      NPC. After an extensive review of journals from various databases (PubMed, the 
      Web of Science, Embase, China National Knowledge Internet (CNKI), and Wanfang 
      Database), 8 out of 69 case-control studies, including 778 cases and 1148 
      controls, were extracted. The results showed that 4 of 13 polymorphisms allele 
      are statistically significantly associated with NPC, among them, HLA-DRB1*3, 
      HLA-DRB1*9, and HLA-DRB1*10 may increase the risk of NPC while HLA-DRB1*01 has 
      the opposite effect. The pooled odds ratio and 95 % confidence interval (CI) were 
      1.702 [95 % CI (1.047, 2.765)], 1.363 [95 % CI (1.029, 1.806)], 1.989 [95 % CI 
      (1.042, 3.799)], and 0.461 [95 % CI (0.315, 0.676)], respectively. In a further 
      ethnicity-based subgroup analysis, HLA-DRB1*08, HLA-DRB1*11, and HLA-DRB1*16 were 
      found to be linked with NPC in Asian, Tunisian, and Caucasian, respectively. In 
      Asian, HLA-DRB1*03, 08, and 10 may elevate the risk whereas HLA-DRB1*09 could 
      lower it. In Tunisian, HLA-DRB1*01 and 11 are the protective factors while 
      HLA-DRB1*03 is the only risk factor. In Caucasian, HLA-DRB1*01 and 03 increase 
      the risk and HLA-DRB1*16 lowers it. The most frequent statistically associated 
      gene is found to be HLA-DRB1*03 which has protective influence on Asian and 
      Tunisian. In conclusion, HLA-DRB1*01, DRB1*03, DRB1*09, and DRB1*10 are related 
      with NPC susceptibility, and the association of HLA-DRB1*08, DRB1*11, and DRB1*16 
      with NPC risk are significantly different in different ethnicities.
FAU - Yang, Huimin
AU  - Yang H
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China.
AD  - Shanghai Biomedical Laboratory, Shanghai, 200436, China.
FAU - Yu, Kaihui
AU  - Yu K
AD  - Department of Pathophysiology, School of Preclinical Sciences, Guangxi Medical 
      University, Nanning, 530021, China.
FAU - Zhang, Ruoheng
AU  - Zhang R
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China.
FAU - Li, Jiatong
AU  - Li J
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China.
FAU - Wei, Xiaomou
AU  - Wei X
AD  - Clinical Laboratory, Guangxi Liuzhou Worker's Hospital, Liuzhou, Guangxi, 545005, 
      China.
FAU - Zhang, Yuening
AU  - Zhang Y
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China.
FAU - Zhang, Chengdong
AU  - Zhang C
AD  - Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, 
      Shiyan, 442001, China.
FAU - Xiao, Feifan
AU  - Xiao F
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China.
FAU - Zhao, Dong
AU  - Zhao D
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China.
FAU - Lin, Xuandong
AU  - Lin X
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China.
FAU - Wu, Huayu
AU  - Wu H
AD  - Department of Cell Biology and Genetics, School of Premedical Sciences, Guangxi 
      Medical University, Nanning, Guangxi, 530021, China. wuhuayu0418@hotmail.com.
FAU - Yang, Xiaoli
AU  - Yang X
AD  - Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 
      530021, China. cncsyxl@126.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160408
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Nasopharyngeal Neoplasms/*genetics/*pathology
MH  - Polymorphism, Genetic/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - Allele
OT  - Ethnic groups
OT  - HLA-DRB1
OT  - Meta-analysis
OT  - Nasopharyngeal carcinoma
OT  - Polymorphisms
EDAT- 2016/04/10 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/04/10 06:00
PHST- 2015/11/26 00:00 [received]
PHST- 2016/04/01 00:00 [accepted]
PHST- 2016/04/10 06:00 [entrez]
PHST- 2016/04/10 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 10.1007/s13277-016-5051-9 [pii]
AID - 10.1007/s13277-016-5051-9 [doi]
PST - ppublish
SO  - Tumour Biol. 2016 Jun;37(6):7119-28. doi: 10.1007/s13277-016-5051-9. Epub 2016 
      Apr 8.