PMID- 27060962
OWN - NLM
STAT- MEDLINE
DCOM- 20170714
LR  - 20180131
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 52
IP  - 3
DP  - 2016 Apr 5
TI  - Longitudinal Study of Impaired Intra- and Inter-Network Brain Connectivity in 
      Subjects at High Risk for Alzheimer's Disease.
PG  - 913-27
LID - 10.3233/JAD-160008 [doi]
AB  - Alzheimer's disease (AD) is associated with abnormal resting-state network (RSN) 
      architecture of the default mode network (DMN), the dorsal attention network 
      (DAN), the executive control network (CON), the salience network (SAL), and the 
      sensory-motor network (SMN). However, little is known about the disrupted intra- 
      and inter-network architecture in mild cognitive impairment (MCI). Here, we 
      employed a priori defined regions of interest to investigate the intra- and 
      inter-network functional connectivity profiles of these RSNs in longitudinal 
      participants, including normal controls (n = 23), participants with early MCI 
      (n = 26), and participants with late MCI (n = 19). We found longitudinal 
      alterations of functional connectivity within the DMN, where they were correlated 
      with variation in cognitive ability. The SAL as well as the interaction between 
      the DMN and the SAL were disrupted in MCI. Furthermore, our results demonstrate 
      that longitudinal alterations of functional connectivity are more profound in 
      earlier stages as opposed to later stages of the disease. The increased severity 
      of cognitive impairment is associated with increasingly altered RSN connectivity 
      patterns, suggesting that disruptions in functional connectivity may contribute 
      to cognitive dysfunction and may represent a potential biomarker of impaired 
      cognitive ability in MCI. Earlier prevention and treatment may help to delay 
      disease progression to AD.
FAU - Zhan, Yafeng
AU  - Zhan Y
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
AD  - Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 
      Beijing, China.
FAU - Ma, Jianhua
AU  - Ma J
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
FAU - Alexander-Bloch, Aaron F
AU  - Alexander-Bloch AF
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
FAU - Xu, Kaibin
AU  - Xu K
AD  - Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 
      Beijing, China.
AD  - National Laboratory of Pattern Recognition, Institute of Automation, Chinese 
      Academy of Sciences, Beijing, China.
FAU - Cui, Yue
AU  - Cui Y
AD  - Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 
      Beijing, China.
AD  - National Laboratory of Pattern Recognition, Institute of Automation, Chinese 
      Academy of Sciences, Beijing, China.
FAU - Feng, Qianjin
AU  - Feng Q
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
FAU - Jiang, Tianzi
AU  - Jiang T
AD  - Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 
      Beijing, China.
AD  - National Laboratory of Pattern Recognition, Institute of Automation, Chinese 
      Academy of Sciences, Beijing, China.
AD  - CAS Center for Excellence in Brain Science, Institute of Automation, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Queensland Brain Institute, University of Queensland, Brisbane, Australia.
FAU - Liu, Yong
AU  - Liu Y
AD  - Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 
      Beijing, China.
AD  - National Laboratory of Pattern Recognition, Institute of Automation, Chinese 
      Academy of Sciences, Beijing, China.
CN  - Alzheimer's Disease Neuroimaging Initiative
LA  - eng
GR  - U01 AG024904/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/diagnostic imaging/*pathology
MH  - Analysis of Variance
MH  - Brain/*pathology
MH  - Canada
MH  - Cognitive Dysfunction/diagnostic imaging/*pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Status Schedule
MH  - Neural Pathways/diagnostic imaging/*pathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - United States
OTO - NOTNLM
OT  - Default mode network
OT  - early mild cognitive impairment
OT  - late mild cognitive impairment
OT  - resting-state network
OT  - salience network
EDAT- 2016/04/12 06:00
MHDA- 2017/07/15 06:00
CRDT- 2016/04/11 06:00
PHST- 2016/04/11 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/07/15 06:00 [medline]
AID - JAD160008 [pii]
AID - 10.3233/JAD-160008 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2016 Apr 5;52(3):913-27. doi: 10.3233/JAD-160008.