PMID- 27061215
OWN - NLM
STAT- MEDLINE
DCOM- 20180214
LR  - 20210103
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Print)
IS  - 1043-3074 (Linking)
VI  - 38
IP  - 8
DP  - 2016 Aug
TI  - Pools of programmed death-ligand within the oral cavity tumor microenvironment: 
      Variable alteration by targeted therapies.
PG  - 1176-86
LID - 10.1002/hed.24269 [doi]
AB  - BACKGROUND: Enhanced understanding of programmed death-ligand (PD-L) expression 
      in oral cancer is important for establishing rational combinations of emerging 
      immune checkpoint and molecular targeted therapies. METHODS: We assessed PD-L and 
      interferon (IFN) expression in immunogenic murine oral cancer-1 (MOC1) and poorly 
      immunogenic MOC2 cell models after treatment with mammalian target of rapamycin 
      (mTOR) and MEK1/2 small molecule inhibitors in vitro and in vivo. RESULTS: PD-L1 
      but not PD-L2 is expressed on MOC1 and 2 cells and is type I and II 
      IFN-dependent. PD-L1 is differentially expressed on cancer and endothelial cells 
      and infiltrating myeloid-derived suppressor cells, macrophages, and regulatory T 
      cells (Tregs) in highly and poorly immunogenic tumors. PD-L1 expression is 
      variably altered after treatment with inhibitors in vivo, with an imperfect 
      relationship to alterations in IFN levels in the tumor microenvironment. 
      CONCLUSION: PD-L1 expressed on cancer and infiltrating immune cells is variably 
      altered by targeted therapies and may, in part, reflect changes in tumor IFN. (c) 
      2016 Wiley Periodicals, Inc. Head Neck 38:1176-1186, 2016.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Shah, Sujay
AU  - Shah S
AD  - Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of 
      Deafness and Other Communication Disorders, National Institutes of Health, 
      Bethesda, Maryland.
FAU - Caruso, Andria
AU  - Caruso A
AD  - Department of Otolaryngology-Head and Neck Surgery, Walter Reed National Military 
      Medical Center, Bethesda, Maryland.
FAU - Cash, Harrison
AU  - Cash H
AD  - Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of 
      Deafness and Other Communication Disorders, National Institutes of Health, 
      Bethesda, Maryland.
FAU - Waes, Carter Van
AU  - Waes CV
AD  - Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of 
      Deafness and Other Communication Disorders, National Institutes of Health, 
      Bethesda, Maryland.
FAU - Allen, Clint T
AU  - Allen CT
AD  - Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of 
      Deafness and Other Communication Disorders, National Institutes of Health, 
      Bethesda, Maryland.
AD  - Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of 
      Medicine, Baltimore, Maryland.
LA  - eng
GR  - ZIA DC000087-01/Intramural NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20160409
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression Regulation, Neoplastic/*drug effects
MH  - Humans
MH  - Immunohistochemistry
MH  - Interferons/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Targeted Therapy/*methods
MH  - Mouth Neoplasms/drug therapy/*genetics/pathology
MH  - Polymerase Chain Reaction/methods
MH  - Programmed Cell Death 1 Receptor/drug effects/*genetics
MH  - Random Allocation
MH  - Tumor Cells, Cultured
MH  - Tumor Microenvironment/*drug effects/genetics
PMC - PMC6669909
MID - NIHMS1042884
OTO - NOTNLM
OT  - interferon
OT  - oral cancer
OT  - programmed death
OT  - targeted therapy
EDAT- 2016/04/12 06:00
MHDA- 2018/02/15 06:00
PMCR- 2019/08/01
CRDT- 2016/04/11 06:00
PHST- 2015/09/13 00:00 [accepted]
PHST- 2016/04/11 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2018/02/15 06:00 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - 10.1002/hed.24269 [doi]
PST - ppublish
SO  - Head Neck. 2016 Aug;38(8):1176-86. doi: 10.1002/hed.24269. Epub 2016 Apr 9.