PMID- 27061551
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20160411
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 21
IP  - 1
DP  - 2016 Jan-Feb
TI  - Factors related to local recurrence of non small cell lung cancer and its 
      operability.
PG  - 221-6
AB  - PURPOSE: To analyze the correlation of primary tumor (PT) pathological 
      characteristics (size, stage, type and grade) and the extent of initial surgical 
      treatment of non small cell lung cancer (NSCLC) with the incidence and time to 
      local recurrence (LR) and disease-free survival (DFS), as well as to determine in 
      what way these parameters and LR localizations affect the possibility for 
      surgical retreatment. METHODS: The research was conducted on 114 patients with 
      NSCLC and LR that had initial surgery in two reference institutes in Serbia from 
      January 2002 to December 2010. PT size and disease stage were defined according 
      to the revised 2004 WHO classification. PTs were grouped by size into 3 
      categories. Due to great diversity, surgical procedures were sorted into 6 
      operation types. Standard statistical methods and tests were used for data 
      analysis. RESULTS: Statistical analyses showed significant difference in DFS and 
      LR reoperability that were related to PT size, disease stage and the extent of 
      initial surgery. LR localization on the chest wall was favorable for secondary 
      surgery due to LR. CONCLUSIONS: Squamous cell lung carcinoma relapses locally 
      more frequently than other lung tumor types, and the commonest LR site is the 
      chest wall. This localization provides high possibility for surgical retreatment. 
      Adequate staging, proper indications for surgical treatment and quality surgery 
      provide longer DFS in patients with NSCLC. All these suggest that the surgeon may 
      be considered as the most significant factor of prognosis.
FAU - Stojiljkovic, Dejan
AU  - Stojiljkovic D
AD  - Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, 
      Belgrade, Serbia.
FAU - Santrac, Nada
AU  - Santrac N
FAU - Goran, Merima
AU  - Goran M
FAU - Stojiljkovic, Tanja
AU  - Stojiljkovic T
FAU - Miletic, Nebojsa
AU  - Miletic N
FAU - Gavrilovic, Dusica
AU  - Gavrilovic D
FAU - Spurnic, Igor
AU  - Spurnic I
FAU - Jevric, Marko
AU  - Jevric M
FAU - Jokic, Stevan
AU  - Jokic S
FAU - Markovic, Ivan
AU  - Markovic I
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/mortality/pathology/*surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/mortality/pathology/*surgery
EDAT- 2016/04/12 06:00
MHDA- 2016/05/18 06:00
CRDT- 2016/04/11 06:00
PHST- 2016/04/11 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PST - ppublish
SO  - J BUON. 2016 Jan-Feb;21(1):221-6.